间隔期结直肠癌的临床与生物学特征
Clinical and Biological Features of Interval Colorectal Cancer.
作者信息
Lee Yu Mi, Huh Kyu Chan
机构信息
Department of Internal Medicine, Konyang University College of Medicine, Daejeon, Korea.
出版信息
Clin Endosc. 2017 May;50(3):254-260. doi: 10.5946/ce.2016.115. Epub 2017 Mar 21.
Abstract
Interval colorectal cancer (I-CRC) is defined as a CRC diagnosed within 60 months after a negative colonoscopy, taking into account that 5 years is the "mean sojourn time." It is important to prevent the development of interval cancer. The development of interval colon cancer is associated with female sex, old age, family history of CRC, comorbidities, diverticulosis, and the skill of the endoscopist. During carcinogenesis, sessile serrated adenomas/polyps (SSA/Ps) share many genomic and colonic site characteristics with I-CRCs. The clinical and biological features of I-CRC should be elucidated to prevent the development of interval colon cancer.
摘要
间期结直肠癌（I-CRC）被定义为在结肠镜检查结果为阴性后的60个月内诊断出的结直肠癌，同时考虑到5年是“平均停留时间”。预防间期癌的发生很重要。间期结肠癌的发生与女性、老年、结直肠癌家族史、合并症、憩室病以及内镜医师的技术有关。在致癌过程中，无蒂锯齿状腺瘤/息肉（SSA/Ps）与I-CRC在许多基因组和结肠部位特征上有共同之处。应阐明I-CRC的临床和生物学特征以预防间期结肠癌的发生。
相似文献
1
Clinical and Biological Features of Interval Colorectal Cancer.间隔期结直肠癌的临床与生物学特征
Clin Endosc. 2017 May;50(3):254-260. doi: 10.5946/ce.2016.115. Epub 2017 Mar 21.
2
Endoscopic characterization of sessile serrated adenomas/polyps with and without dysplasia.伴有和不伴有发育异常的无蒂锯齿状腺瘤/息肉的内镜特征
Endoscopy. 2014 Mar;46(3):225-35. doi: 10.1055/s-0034-1364936. Epub 2014 Feb 26.
3
Findings in the distal colorectum are not associated with proximal advanced serrated lesions.远端结直肠的病变与近端高级锯齿状病变无关。
Clin Gastroenterol Hepatol. 2015 Feb;13(2):345-51. doi: 10.1016/j.cgh.2014.07.044. Epub 2014 Jul 30.
4
Increased Risk of Colorectal Cancer Development Among Patients With Serrated Polyps.锯齿状息肉患者结直肠癌发病风险增加。
Gastroenterology. 2016 Apr;150(4):895-902.e5. doi: 10.1053/j.gastro.2015.11.046. Epub 2015 Dec 8.
5
Characteristics of missed or interval colorectal cancer and patient survival: a population-based study.漏诊或间隔期结直肠癌的特征和患者生存：一项基于人群的研究。
Gastroenterology. 2014 Apr;146(4):950-60. doi: 10.1053/j.gastro.2014.01.013. Epub 2014 Jan 11.
6
Volumetric growth rates of sessile serrated adenomas/polyps observed in situ at longitudinal CT colonography.在纵向 CT 结肠成像中观察到的无蒂锯齿状腺瘤/息肉的体积增长率。
Eur Radiol. 2019 Sep;29(9):5093-5100. doi: 10.1007/s00330-019-5999-0. Epub 2019 Feb 11.
7
The association between colorectal sessile serrated adenomas/polyps and subsequent advanced colorectal neoplasia.结直肠无蒂锯齿状腺瘤/息肉与随后发生的高级别结直肠肿瘤之间的关联。
Cancer Causes Control. 2019 Sep;30(9):979-987. doi: 10.1007/s10552-019-01205-y. Epub 2019 Jul 9.
8
Clinical and endoscopic predictors of cytological dysplasia or cancer in a prospective multicentre study of large sessile serrated adenomas/polyps.在一项大型无蒂锯齿状腺瘤/息肉的前瞻性多中心研究中，细胞学异型增生或癌症的临床和内镜预测因子。
Gut. 2016 Mar;65(3):437-46. doi: 10.1136/gutjnl-2014-308603. Epub 2015 Mar 2.
9
Prevalence, distribution and risk of sessile serrated adenomas/polyps at a center with a high adenoma detection rate and experienced pathologists.高腺瘤检出率和经验丰富病理学家中心的息肉样锯齿状腺瘤/息肉的流行率、分布和风险。
Endoscopy. 2016 Aug;48(8):740-6. doi: 10.1055/s-0042-105436. Epub 2016 Apr 25.
10
Sessile serrated polyps at screening colonoscopy: have they been under diagnosed?筛查性结肠镜检查中的无蒂锯齿状息肉：它们是否被漏诊了？
Am J Gastroenterol. 2014 Nov;109(11):1698-704. doi: 10.1038/ajg.2014.78. Epub 2014 Jul 8.
引用本文的文献
1
Assessment of the impact of multi-cancer early detection test screening intervals on late-stage cancer at diagnosis and mortality using a state-transition model.使用状态转换模型评估多癌早期检测测试筛查间隔对诊断时晚期癌症和死亡率的影响。
BMJ Open. 2025 May 8;15(5):e086648. doi: 10.1136/bmjopen-2024-086648.
2
Immunohistochemical insights into the pathogenesis of colonic sessile serrated lesions.结肠无蒂锯齿状病变发病机制的免疫组化研究
Arch Clin Cases. 2025 Mar 25;12(1):22-28. doi: 10.22551/2025.46.1201.10307. eCollection 2025.
3
The Impact of Age on Preferences for Colorectal Cancer Surveillance Strategies: Are Fecal Immunochemical Tests FIT for Surveillance?年龄对结直肠癌监测策略偏好的影响：粪便免疫化学检测是否适合用于监测？
Cancer Med. 2025 Mar;14(5):e70723. doi: 10.1002/cam4.70723.
4
Clinicopathological and molecular differences between stage IV screen-detected and interval colorectal cancers in the Flemish screening program.弗拉芒筛查项目中IV期筛查发现的结直肠癌与间期结直肠癌之间的临床病理及分子差异
Front Oncol. 2024 Sep 2;14:1409196. doi: 10.3389/fonc.2024.1409196. eCollection 2024.
5
Postcolonoscopy Colorectal Cancer in a Referral Center for Colorectal Cancer: Prevalence and Risk Factors.一家结直肠癌转诊中心的结肠镜检查后结直肠癌：患病率及危险因素
GE Port J Gastroenterol. 2022 Sep 6;30(5):359-367. doi: 10.1159/000526126. eCollection 2023 Oct.
6
Improved use of faecal immunochemical tests for haemoglobin in the Scottish bowel screening programme.提高粪便免疫化学试验在苏格兰肠道筛查计划中检测血红蛋白的应用。
J Med Screen. 2023 Dec;30(4):184-190. doi: 10.1177/09691413231175611. Epub 2023 May 25.
7
Sessile serrated lesions with dysplasia: is it possible to nip them in the bud?无蒂锯齿状病变伴异型增生：是否有可能防患于未然？
J Gastroenterol. 2023 Aug;58(8):705-717. doi: 10.1007/s00535-023-02003-9. Epub 2023 May 23.
8
Weakly Supervised Polyp Segmentation in Colonoscopy Images Using Deep Neural Networks.利用深度神经网络进行结肠镜检查图像的弱监督息肉分割
J Imaging. 2022 Apr 22;8(5):121. doi: 10.3390/jimaging8050121.
9
Most large colorectal polyps missed by gastroenterology fellows at colonoscopy are sessile serrated lesions.胃肠病学进修医生在结肠镜检查时漏诊的大多数大肠大息肉是无蒂锯齿状病变。
Endosc Int Open. 2022 May 13;10(5):E659-E663. doi: 10.1055/a-1784-0959. eCollection 2022 May.
10
Mutations as Potential Predictors for Recurrence in Colorectal Serrated Polyps by Targeted Next-Generation Sequencing.通过靶向二代测序分析突变作为大肠锯齿状息肉复发的潜在预测指标
Front Oncol. 2022 Mar 23;12:769709. doi: 10.3389/fonc.2022.769709. eCollection 2022.
本文引用的文献
1
Prevalence, risk factors, and outcomes of interval colorectal cancers: a systematic review and meta-analysis.间隔期结直肠癌的流行率、风险因素和结局：系统评价和荟萃分析。
Am J Gastroenterol. 2014 Sep;109(9):1375-89. doi: 10.1038/ajg.2014.171. Epub 2014 Jun 24.
2
Establishing a biological profile for interval colorectal cancers.建立结直肠癌间期的生物学特征。
Dig Dis Sci. 2014 Oct;59(10):2390-402. doi: 10.1007/s10620-014-3210-7. Epub 2014 May 20.
3
Characteristics of missed or interval colorectal cancer and patient survival: a population-based study.漏诊或间隔期结直肠癌的特征和患者生存：一项基于人群的研究。
Gastroenterology. 2014 Apr;146(4):950-60. doi: 10.1053/j.gastro.2014.01.013. Epub 2014 Jan 11.
4
Long-term colorectal-cancer incidence and mortality after lower endoscopy.结肠镜检查后的结直肠癌长期发病率和死亡率。
N Engl J Med. 2013 Sep 19;369(12):1095-105. doi: 10.1056/NEJMoa1301969.
5
Colorectal cancers soon after colonoscopy: a pooled multicohort analysis.结肠镜检查后不久的结直肠癌： pooled 多队列分析。
Gut. 2014 Jun;63(6):949-56. doi: 10.1136/gutjnl-2012-303796. Epub 2013 Jun 21.
6
Characteristics and survival of interval and sporadic colorectal cancer patients: a nationwide population-based cohort study.间隔期和偶发性结直肠癌患者的特征和生存情况：一项全国范围内基于人群的队列研究。
Am J Gastroenterol. 2013 Aug;108(8):1332-40. doi: 10.1038/ajg.2013.175. Epub 2013 Jun 18.
7
Postcolonoscopy colorectal cancers are preventable: a population-based study.结肠镜检查后的结直肠癌是可以预防的：一项基于人群的研究。
Gut. 2014 Jun;63(6):957-63. doi: 10.1136/gutjnl-2013-304880. Epub 2013 Jun 6.
8
The serrated pathway to colorectal carcinoma: current concepts and challenges.锯齿状途径与结直肠癌：当前概念与挑战。
Histopathology. 2013 Feb;62(3):367-86. doi: 10.1111/his.12055.
9
Rate of early/missed colorectal cancers after colonoscopy in older patients with or without inflammatory bowel disease in the United States.美国老年患者结肠镜检查后早期/漏诊结直肠癌的发生率，无论是否患有炎症性肠病。
Am J Gastroenterol. 2013 Mar;108(3):444-9. doi: 10.1038/ajg.2012.429. Epub 2013 Jan 8.
10
Serrated lesions of the colorectum: review and recommendations from an expert panel.结直肠锯齿状病变：专家小组的综述和建议。
Am J Gastroenterol. 2012 Sep;107(9):1315-29; quiz 1314, 1330. doi: 10.1038/ajg.2012.161. Epub 2012 Jun 19.
Zotero 插件