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本文引用的文献

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Prevalence, risk factors, and outcomes of interval colorectal cancers: a systematic review and meta-analysis.间隔期结直肠癌的流行率、风险因素和结局：系统评价和荟萃分析。
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Establishing a biological profile for interval colorectal cancers.建立结直肠癌间期的生物学特征。
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Characteristics of missed or interval colorectal cancer and patient survival: a population-based study.漏诊或间隔期结直肠癌的特征和患者生存：一项基于人群的研究。
Gastroenterology. 2014 Apr;146(4):950-60. doi: 10.1053/j.gastro.2014.01.013. Epub 2014 Jan 11.
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Long-term colorectal-cancer incidence and mortality after lower endoscopy.结肠镜检查后的结直肠癌长期发病率和死亡率。
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Colorectal cancers soon after colonoscopy: a pooled multicohort analysis.结肠镜检查后不久的结直肠癌： pooled 多队列分析。
Gut. 2014 Jun;63(6):949-56. doi: 10.1136/gutjnl-2012-303796. Epub 2013 Jun 21.
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Characteristics and survival of interval and sporadic colorectal cancer patients: a nationwide population-based cohort study.间隔期和偶发性结直肠癌患者的特征和生存情况：一项全国范围内基于人群的队列研究。
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Postcolonoscopy colorectal cancers are preventable: a population-based study.结肠镜检查后的结直肠癌是可以预防的：一项基于人群的研究。
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The serrated pathway to colorectal carcinoma: current concepts and challenges.锯齿状途径与结直肠癌：当前概念与挑战。
Histopathology. 2013 Feb;62(3):367-86. doi: 10.1111/his.12055.
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Rate of early/missed colorectal cancers after colonoscopy in older patients with or without inflammatory bowel disease in the United States.美国老年患者结肠镜检查后早期/漏诊结直肠癌的发生率，无论是否患有炎症性肠病。
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间隔期结直肠癌的临床与生物学特征

Clinical and Biological Features of Interval Colorectal Cancer.

作者信息

Lee Yu Mi, Huh Kyu Chan

机构信息

Department of Internal Medicine, Konyang University College of Medicine, Daejeon, Korea.

出版信息

Clin Endosc. 2017 May;50(3):254-260. doi: 10.5946/ce.2016.115. Epub 2017 Mar 21.

DOI:10.5946/ce.2016.115
PMID:28320200
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5475521/
Abstract

Interval colorectal cancer (I-CRC) is defined as a CRC diagnosed within 60 months after a negative colonoscopy, taking into account that 5 years is the "mean sojourn time." It is important to prevent the development of interval cancer. The development of interval colon cancer is associated with female sex, old age, family history of CRC, comorbidities, diverticulosis, and the skill of the endoscopist. During carcinogenesis, sessile serrated adenomas/polyps (SSA/Ps) share many genomic and colonic site characteristics with I-CRCs. The clinical and biological features of I-CRC should be elucidated to prevent the development of interval colon cancer.

摘要

间期结直肠癌（I-CRC）被定义为在结肠镜检查结果为阴性后的60个月内诊断出的结直肠癌，同时考虑到5年是“平均停留时间”。预防间期癌的发生很重要。间期结肠癌的发生与女性、老年、结直肠癌家族史、合并症、憩室病以及内镜医师的技术有关。在致癌过程中，无蒂锯齿状腺瘤/息肉（SSA/Ps）与I-CRC在许多基因组和结肠部位特征上有共同之处。应阐明I-CRC的临床和生物学特征以预防间期结肠癌的发生。