移植物抗宿主病后口腔多发复发性鳞状细胞癌
Multiple and Recurrent Squamous Cell Carcinoma of the Oral Cavity After Graft-Versus-Host Disease.
作者信息
Weng Xiuhong, Xing Yuzhen, Cheng Bo
机构信息
Resident, Department of Stomatology, Wuhan Union Hospital, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan, China.
Associated Professor, Department of Stomatology, Wuhan Union Hospital, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan, China.
出版信息
J Oral Maxillofac Surg. 2017 Sep;75(9):1899-1905. doi: 10.1016/j.joms.2017.02.012. Epub 2017 Feb 22.
Oral squamous cell carcinoma (OSCC) is one of the most common secondary solid tumors in patients who have undergone hematopoietic stem cell transplantation (HSCT). However, according to previous reports, multiple and recurrent OSCC is very rare. The presented case shows the susceptibility to the development of secondary malignancies, particularly oral cancer, of patients who present with chronic graft-versus-host disease after HSCT. OSCC after HSCT appears to be more invasive and has a tendency to recur, with a poor prognosis. Therefore, regular and thorough evaluations of the oral mucosa are recommended for all patients who undergo bone marrow transplantation and have chronic graft-versus-host disease.
口腔鳞状细胞癌（OSCC）是接受造血干细胞移植（HSCT）患者中最常见的继发性实体肿瘤之一。然而，根据既往报道，多发和复发性OSCC非常罕见。本病例显示了HSCT后出现慢性移植物抗宿主病的患者发生继发性恶性肿瘤，尤其是口腔癌的易感性。HSCT后的OSCC似乎更具侵袭性且有复发倾向，预后较差。因此，建议对所有接受骨髓移植且患有慢性移植物抗宿主病的患者进行定期、全面的口腔黏膜评估。
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