淀粉样蛋白β与脑白质高信号的相关性：系统综述。
Associations between amyloid β and white matter hyperintensities: A systematic review.
机构信息
LC Campbell Cognitive Neurology Research Unit, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Heart & Stroke Foundation Canadian Partnership for Stroke Recovery, Toronto, Ontario, Canada.
出版信息
Alzheimers Dement. 2017 Oct;13(10):1154-1167. doi: 10.1016/j.jalz.2017.01.026. Epub 2017 Mar 16.
INTRODUCTION
This systematic review synthesizes current evidence for associations between cortical amyloid β, visualized on amyloid positron emission tomography imaging, and white matter hyperintensity (WMH) burden on magnetic resonance imaging in healthy elderly adults and individuals with cognitive impairment and dementia.
METHODS
Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) systematic review guidelines, we systematically searched MEDLINE, Embase, Cochrane, and PsycINFO databases from January 2000 to September 2015.
RESULTS
Our search returned 492 articles, 34 of which met criteria for inclusion in the final selection. Most studies reported no significant relationships between amyloid β and WMH burden across diagnostic groups.
DISCUSSION
Findings of this systematic review suggest that amyloid accumulation and WMH are independent but additive processes. The limited number of independent cohorts, lack of longitudinal data, and exclusion of individuals with mixed dementia limit the generalizability of these findings. Further studies are required to elucidate the putative contributions of vascular processes to neurodegenerative pathology.
简介
本系统综述综合了目前关于皮质淀粉样蛋白β（在正电子发射断层扫描成像上显示）与健康老年人及认知障碍和痴呆患者磁共振成像上的脑白质高信号（WMH）负荷之间关联的证据。
方法
我们根据系统综述和荟萃分析的首选报告项目（PRISMA）指南，系统地检索了从 2000 年 1 月至 2015 年 9 月的 MEDLINE、Embase、Cochrane 和 PsycINFO 数据库。
结果
我们的检索共返回了 492 篇文章，其中 34 篇符合最终入选标准。大多数研究报告称，在不同的诊断组中，淀粉样蛋白β与 WMH 负担之间没有显著关系。
讨论
本系统综述的结果表明，淀粉样蛋白的积累和 WMH 是独立但累加的过程。这些发现的普遍性受到有限数量的独立队列、缺乏纵向数据以及排除混合性痴呆患者的限制。需要进一步的研究来阐明血管过程对神经退行性病理的可能贡献。
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