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Incontinence: How do β-adrenoceptor agonists work in the bladder?

作者信息

Igawa Yasuhiko, Aizawa Naoki

机构信息

Department of Continence Medicine, The University of Tokyo Graduate School of Medicine, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

出版信息

Nat Rev Urol. 2017 Jun;14(6):330-332. doi: 10.1038/nrurol.2017.43. Epub 2017 Mar 21.

DOI:10.1038/nrurol.2017.43
PMID:28322259
Abstract
摘要

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[Overactive bladder - relaxed by selective adrenergic agonists?].
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Beta-3 adrenergic receptor is expressed in acetylcholine-containing nerve fibers of the human urinary bladder: An immunohistochemical study.β-3肾上腺素能受体在人膀胱含乙酰胆碱神经纤维中的表达：一项免疫组织化学研究。
Neurourol Urodyn. 2017 Nov;36(8):1972-1980. doi: 10.1002/nau.23224. Epub 2017 Feb 10.
2
Efficacy and Safety of Mirabegron Add-on Therapy to Solifenacin in Incontinent Overactive Bladder Patients with an Inadequate Response to Initial 4-Week Solifenacin Monotherapy: A Randomised Double-blind Multicentre Phase 3B Study (BESIDE).米拉贝隆附加治疗对初始 4 周索利那新单药治疗反应不足的失禁型逼尿过度活动症患者的疗效和安全性：一项随机双盲多中心 3B 期研究（BESIDE）。
Eur Urol. 2016 Jul;70(1):136-145. doi: 10.1016/j.eururo.2016.02.030. Epub 2016 Mar 8.
3
β肾上腺素能受体诱导的人和大鼠膀胱胆碱能抑制涉及由环磷酸腺苷1直接激活的交换蛋白，有利于腺苷释放。
Br J Pharmacol. 2020 Apr;177(7):1589-1608. doi: 10.1111/bph.14921. Epub 2020 Feb 6.
Physiological and pathophysiological implications of micromotion activity in urinary bladder function.膀胱功能中微动活动的生理和病理生理学意义。
Acta Physiol (Oxf). 2015 Feb;213(2):360-70. doi: 10.1111/apha.12373. Epub 2014 Sep 27.
4
Modulation of nerve-evoked contractions by β3-adrenoceptor agonism in human and rat isolated urinary bladder.β3肾上腺素能受体激动对人和大鼠离体膀胱神经诱发收缩的调节作用
Pharmacol Res. 2014 Feb;80:14-20. doi: 10.1016/j.phrs.2013.12.006. Epub 2013 Dec 28.
5
Urodynamics and safety of the β₃-adrenoceptor agonist mirabegron in males with lower urinary tract symptoms and bladder outlet obstruction.男性下尿路症状和膀胱出口梗阻患者中 β₃-肾上腺素能受体激动剂米拉贝隆的尿动力学和安全性。
J Urol. 2013 Oct;190(4):1320-7. doi: 10.1016/j.juro.2013.05.062. Epub 2013 May 30.
6
Effects of mirabegron, a novel β3-adrenoceptor agonist, on primary bladder afferent activity and bladder microcontractions in rats compared with the effects of oxybutynin.米拉贝隆（一种新型β3-肾上腺素能受体激动剂）对大鼠初级膀胱传入活动和膀胱微收缩的影响与奥昔布宁的影响比较。
Eur Urol. 2012 Dec;62(6):1165-73. doi: 10.1016/j.eururo.2012.08.056. Epub 2012 Sep 5.
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Specificity evaluation of antibodies against human β3-adrenoceptors.抗人β3-肾上腺素能受体抗体的特异性评价。
Naunyn Schmiedebergs Arch Pharmacol. 2012 Sep;385(9):875-82. doi: 10.1007/s00210-012-0767-6. Epub 2012 Jun 12.
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β-Adrenergic receptor subtype expression in myocyte and non-myocyte cells in human female bladder.人女性膀胱中肌细胞和非肌细胞β肾上腺素能受体亚型的表达。
Cell Tissue Res. 2010 Nov;342(2):295-306. doi: 10.1007/s00441-010-1053-x. Epub 2010 Oct 16.
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Effect of (R)-2-(2-aminothiazol-4-yl)-4'-{2-[(2-hydroxy-2-phenylethyl)amino]ethyl} acetanilide (YM178), a novel selective beta3-adrenoceptor agonist, on bladder function.新型选择性β3肾上腺素能受体激动剂（R）-2-（2-氨基噻唑-4-基）-4'-{2-[(2-羟基-2-苯乙基)氨基]乙基}乙酰苯胺（YM178）对膀胱功能的影响
J Pharmacol Exp Ther. 2007 May;321(2):642-7. doi: 10.1124/jpet.106.115840. Epub 2007 Feb 9.
10
Localized contractions in the normal human bladder and in urinary urgency.正常人体膀胱中的局部收缩与尿急
BJU Int. 2005 May;95(7):1002-5. doi: 10.1111/j.1464-410X.2005.05455.x.