类风湿关节炎成纤维细胞样滑膜细胞中的表观遗传改变。
Epigenetic alterations in rheumatoid arthritis fibroblast-like synoviocytes.
作者信息
Doody Karen M, Bottini Nunzio, Firestein Gary S
机构信息
Grenfell Campus, Memorial University of Newfoundland, Corner Brook, Newfoundland, Canada.
Division of Rheumatology, Allergy & Immunology, University of California, San Diego School of Medicine, La Jolla, CA, USA.
出版信息
Epigenomics. 2017 Apr;9(4):479-492. doi: 10.2217/epi-2016-0151. Epub 2017 Mar 21.
Abstract
Rheumatoid arthritis is an immune-mediated disease that primarily affects diarthrodial joints. Susceptibility and severity of this disease are influenced by nongenetic factors, such as environmental stress, suggesting an important role of epigenetic changes. In this review, we summarize the epigenetic changes (DNA methylation, histone modification and miRNA expression) in fibroblast-like synoviocytes, which are the joint-lining mesenchymal cells that play an important role in joint inflammation and damage. We also review the effects of these epigenetic changes on rheumatoid arthritis pathogenesis and discuss their therapeutic potential.
摘要
类风湿性关节炎是一种主要影响滑膜关节的免疫介导疾病。这种疾病的易感性和严重程度受非遗传因素影响，如环境压力，这表明表观遗传变化起着重要作用。在本综述中，我们总结了成纤维样滑膜细胞中的表观遗传变化（DNA甲基化、组蛋白修饰和miRNA表达），成纤维样滑膜细胞是关节衬里间充质细胞，在关节炎症和损伤中起重要作用。我们还综述了这些表观遗传变化对类风湿性关节炎发病机制的影响，并讨论了它们的治疗潜力。
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