Institute of Clinical Pharmacology, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Anhui Medical University, Hefei, China.
Department of Neurosurgery, First Affiliated Hospital of Anhui Medical University, Hefei, China.
Mediators Inflamm. 2018 May 10;2018:9013124. doi: 10.1155/2018/9013124. eCollection 2018.
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the posttranscriptional level via direct binding to the 3'-untranslated region (UTR) of target mRNAs. Emerging evidence shows that miRNAs play crucial roles in controlling and modulating immune system-related diseases. This review focuses on the role played by miRNAs in fibroblast-like synoviocytes (FLS), which is a key cellular component within synovia, during the establishment and maintenance of rheumatoid arthritis (RA), a systemic inflammatory autoimmune disease. It also provides an overview and classification of known functional miRNAs in RA FLS and summarizes the potential uses of these small molecules in RA diagnosis and treatment.
微小 RNA（miRNAs）是一类小的非编码 RNA，可以通过与靶 mRNA 的 3'-非翻译区（UTR）直接结合来调节基因表达的转录后水平。越来越多的证据表明，miRNAs 在调控免疫系统相关疾病中发挥着至关重要的作用。本综述重点介绍了 miRNA 在类风湿关节炎（RA）中滑膜成纤维样细胞（FLS）中的作用，滑膜成纤维样细胞是滑膜中的一个关键细胞成分。本文还概述并分类了 RA FLS 中已知的功能性 miRNAs，并总结了这些小分子在 RA 诊断和治疗中的潜在用途。
