功能性胎儿调节性 T 细胞缺失导致人类子宫内器官特异性自身免疫。
Absence of functional fetal regulatory T cells in humans causes in utero organ-specific autoimmunity.
机构信息
Department of Pediatrics, University of Washington School of Medicine, Seattle, Wash; Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, Wash.
Department of Laboratories, Seattle Children's Hospital, Seattle, Wash; Department of Pathology, University of Washington School of Medicine, Seattle, Wash.
出版信息
J Allergy Clin Immunol. 2017 Aug;140(2):616-619.e7. doi: 10.1016/j.jaci.2017.02.017. Epub 2017 Mar 16.
Abstract
Regulatory T cells play a critical role in preventing fetal organ-specific autoimmunity in humans. Autopsies of neonatal IPEX patients shortly after birth demonstrate chronic exocrine-dominant pancreatitis with tertiary lymphoid structures containing expanded oligoclonal T/B lymphocytes.
摘要
调节性 T 细胞在预防人类胎儿器官特异性自身免疫中起着关键作用。在 IPEX 新生儿出生后不久进行的尸检中，观察到以慢性外分泌为主的胰腺炎，伴有包含扩增的寡克隆 T/B 淋巴细胞的三级淋巴结构。
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本文引用的文献
1
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Am J Med Genet A. 2016 Jan;170A(1):226-32. doi: 10.1002/ajmg.a.37401. Epub 2015 Sep 23.
2
Timely and spatially regulated maturation of B and T cell repertoire during human fetal development.人类胎儿发育过程中 B 和 T 细胞 repertoire 的适时和空间调节成熟。
Sci Transl Med. 2015 Feb 25;7(276):276ra25. doi: 10.1126/scitranslmed.aaa0072.
3
Dynamics of the cytotoxic T cell response to a model of acute viral infection.细胞毒性T细胞对急性病毒感染模型反应的动力学
J Virol. 2015 Apr;89(8):4517-26. doi: 10.1128/JVI.03474-14. Epub 2015 Feb 4.
4
Fetal-onset IPEX: report of two families and review of literature.胎儿起病的 IPEX 综合征：两大家族的报告及文献复习。
Clin Immunol. 2015 Feb;156(2):131-40. doi: 10.1016/j.clim.2014.12.007. Epub 2014 Dec 27.
5
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J Pediatr Gastroenterol Nutr. 2016 Nov;63(5):e119-e120. doi: 10.1097/MPG.0000000000000554.
6
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7
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9
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