垂体显微手术后的促肾上腺皮质激素释放激素（CRH）试验表明，库欣病手术成功的患者存在继发性肾上腺皮质功能不全。
CRH test after pituitary microsurgery suggests tertiary adrenocortical insufficiency in successful operated patients with Cushing's disease.
作者信息
Schrell U, Fahlbusch R, Buchfelder M, Riedl S, Stalla G K, Müller O A
机构信息
Neurochirurgische Klinik, University of Erlangen-Nürberg, West Germany.
出版信息
Horm Metab Res Suppl. 1987;16:64-5.
In this study 30 patients with ACTH-dependent Cushing's disease underwent CRH-stimulation test before, 7-10 days and 3-6 months later after transphenoidal selective microadenomectomy. In 22 of 30 patients clinical and endocrinological remission (2 mg dexamethasone suppression test below 2 micrograms/dl cortisol) occurred. Fourteen of the 22 patients in remission showed a statistically significant increase of ACTH after CRH, 1 week after the operation. This CRH-induced ACTH increase in the early post-operative period gives indirect evidence for endogenous CRH deficiency and suggests tertiary adrenocortical insufficiency in successfully operated patients.
在本研究中，30例促肾上腺皮质激素（ACTH）依赖性库欣病患者在经蝶窦选择性微腺瘤切除术前、术后7 - 10天及3 - 6个月接受了促肾上腺皮质激素释放激素（CRH）刺激试验。30例患者中有22例实现了临床和内分泌缓解（2毫克地塞米松抑制试验中皮质醇低于2微克/分升）。缓解的22例患者中有14例在术后1周接受CRH刺激后ACTH有统计学意义的升高。术后早期这种CRH诱导的ACTH升高间接证明了内源性CRH缺乏，并提示手术成功的患者存在三级肾上腺皮质功能不全。
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