肿瘤坏死因子β（淋巴毒素）可抑制中性粒细胞的运动，并刺激其呼吸爆发和脱颗粒。
Tumour necrosis factor beta (lymphotoxin) inhibits locomotion and stimulates the respiratory burst and degranulation of neutrophils.
作者信息
Ferrante A, Nandoskar M, Bates E J, Goh D H, Beard L J
机构信息
University Department of Paediatrics, Adelaide Children's Hospital, South Australia.
出版信息
Immunology. 1988 Mar;63(3):507-12.
Abstract
The data presented here demonstrate that recombinant human tumour necrosis factor beta (rHuTNF beta; lymphotoxin) is a neutrophil modulator. The lymphokine inhibited the locomotion of neutrophils and augmented the neutrophil oxygen-dependent respiratory burst in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP) and phorbol myristate acetate (PMA), as measured by their capacity to produce chemiluminescence, H2O2 and superoxide. The effects on the respiratory burst occurred at a tenth of the concentration of TNF beta required to inhibit locomotion. After incubation with TNF beta, the neutrophils could be washed without any reduction in their capacity to show augmented responses. The TNF beta enhanced granule enzyme (lysozyme and beta-glucuronidase) release of neutrophils stimulated with cytochalasin B-FMLP.
摘要
此处呈现的数据表明，重组人肿瘤坏死因子β（rHuTNFβ；淋巴毒素）是一种中性粒细胞调节剂。该淋巴因子抑制中性粒细胞的运动，并增强中性粒细胞对N-甲酰-L-蛋氨酰-L-亮氨酰-L-苯丙氨酸（FMLP）和佛波酯肉豆蔻酸酯乙酸酯（PMA）的氧依赖性呼吸爆发，通过它们产生化学发光、H2O2和超氧化物的能力来衡量。对呼吸爆发的影响发生在抑制运动所需的TNFβ浓度的十分之一时。用TNFβ孵育后，中性粒细胞可以被洗涤，而其显示增强反应的能力不会降低。TNFβ增强了用细胞松弛素B-FMLP刺激的中性粒细胞的颗粒酶（溶菌酶和β-葡萄糖醛酸酶）释放。
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