肿瘤坏死因子调节人中性粒细胞上白三烯B4受体的亲和力状态。
Tumour necrosis factors modulate the affinity state of the leukotriene B4 receptor on human neutrophils.
作者信息
Brom J, Knöller J, Köller M, König W
机构信息
Lehrstuhl für Medizinische Mikrobiologie und Immunologie, Arbeitsgruppe für Infektabwehrmechanismen, Ruhr-Universität Bochum, FRG.
出版信息
Immunology. 1988 Dec;65(4):647-9.
Abstract
Pre-incubation of human polymorphonuclear granulocytes with recombinant human tumour necrosis factors (TNF) revealed a time- and dose-dependent reduction of the expression of leukotriene B4-receptor sites. Analysis of the binding data by Scatchard plots showed a shift from a heterologous receptor population (indicating high- and low-affinity subsets) to a homologous population. From the results it is considered that TNF can influence host defence through the modulation of leukotriene B4 receptor affinity.
摘要
用人重组肿瘤坏死因子（TNF）对人多形核粒细胞进行预孵育，结果显示白三烯B4受体位点的表达呈时间和剂量依赖性降低。通过Scatchard图分析结合数据表明，受体群体从异源群体（表明存在高亲和力和低亲和力亚群）转变为同源群体。从结果来看，认为TNF可通过调节白三烯B4受体亲和力来影响宿主防御。
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