Pigula Anne J, Wu Jim S, Gilbertson Matthew W, Darras Basil T, Rutkove Seward B, Anthony Brian W
Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug;2016:2865-2868. doi: 10.1109/EMBC.2016.7591327.
The purpose of this study is to assess differences in skeletal muscle compressibility between patients with Duchenne muscular dystrophy (DMD) and normal subjects. The transverse passive mechanical properties of muscle, particularly those related to stiffness and elasticity, can be measured using force-controlled ultrasound. We acquired ultrasound videos of muscle compression under known pressures in the biceps and quadriceps in 23 boys with DMD and 20 age-matched healthy controls. We calculated the bulk linear spring constant, nonlinear stress-strain response, and average Young's modulus for each. Young's modulus was found to be significantly higher in the DMD population in both the biceps (normal: 33 ± 6 kPa, DMD: 45 ± 14, p <; .01) and quadriceps (normal: 42 ± 6, DMD: 58 ± 14, p <; .0001). Muscle compressibility measured by force-controlled ultrasound is an objective and robust technique to quantitatively monitor the effects of DMD and distinguish from normal subjects.
本研究的目的是评估杜氏肌营养不良症（DMD）患者与正常受试者之间骨骼肌可压缩性的差异。肌肉的横向被动力学特性，尤其是与刚度和弹性相关的特性，可以使用力控超声进行测量。我们获取了23名患有DMD的男孩和20名年龄匹配的健康对照者在已知压力下肱二头肌和股四头肌肌肉压缩的超声视频。我们分别计算了每组的体积线性弹簧常数、非线性应力应变响应和平均杨氏模量。结果发现，肱二头肌（正常：33±6 kPa，DMD：45±14，p<0.01）和股四头肌（正常：42±6，DMD：58±14，p<0.0001）的DMD患者组的杨氏模量均显著更高。通过力控超声测量的肌肉可压缩性是一种客观且可靠的技术，可用于定量监测DMD的影响并与正常受试者区分开来。
