Seo Dong-Kyo, Lee Ho Seong, Park Jungu, Ryu Chang Hyun, Han Duck Jong, Seo Sang Gyo
1 Department of Orthopedic Surgery, Gangneung Asan Hospital, College of Medicine, University of Ulsan, Seoul, Republic of Korea.
2 Department of Orthopedic Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Foot Ankle Int. 2017 Jun;38(6):656-661. doi: 10.1177/1071100717696246. Epub 2017 Mar 22.
It is known that successful pancreas transplantation enables patients with diabetes to maintain a normal glucose level without insulin and reduces diabetes-related complications. However, we have little information about the foot-specific morbidity in patients who have undergone successful pancreas transplantation. The purpose of this study was to investigate the prevalence and predisposing factors for foot complications after successful pancreas transplantation.
This retrospective study included 218 patients (91 males, 127 females) who had undergone pancreas transplantation for diabetes. The mean age was 40.7 (range, 15-76) years. Diabetes type, transplantation type, body mass index, and diabetes duration before transplantation were confirmed. After pancreas transplantation, the occurrence and duration of foot and ankle complications were assessed.
Twenty-two patients (10.1%) had diabetic foot complications. Fifteen patients (6.9%) had diabetic foot ulcer and 7 patients (3.2%) had Charcot arthropathy. Three patients had both diabetic foot ulcer and Charcot arthropathy. Three insufficiency fractures (1.4%) were included. Mean time of complications after transplantation was 18.5 (range, 2-77) months. Creatinine level 1 year after surgery was higher in the complication group rather than the noncomplication group ( P = .02).
Complications of the foot and ankle still occurred following pancreas transplantation in patients with diabetes.
Level III, comparative study.
众所周知，成功的胰腺移植能使糖尿病患者在不使用胰岛素的情况下维持正常血糖水平，并减少糖尿病相关并发症。然而，我们对成功接受胰腺移植患者足部特定发病率的了解甚少。本研究的目的是调查成功胰腺移植后足部并发症的患病率及易感因素。
这项回顾性研究纳入了218例因糖尿病接受胰腺移植的患者（男性91例，女性127例）。平均年龄为40.7岁（范围15 - 76岁）。确认了糖尿病类型、移植类型、体重指数以及移植前糖尿病病程。胰腺移植后，评估足部和踝关节并发症的发生情况及持续时间。
22例患者（10.1%）出现糖尿病足部并发症。15例患者（6.9%）发生糖尿病足溃疡，7例患者（3.2%）出现夏科氏关节病。3例患者同时患有糖尿病足溃疡和夏科氏关节病。包括3例不全骨折（1.4%）。移植后并发症的平均发生时间为18.5个月（范围2 - 77个月）。并发症组术后1年的肌酐水平高于无并发症组（P = 0.02）。
糖尿病患者胰腺移植后仍会出现足部和踝关节并发症。
三级，比较性研究。
