中国北京初治HIV-1感染学生中传播性耐药率较低
Low Rates of Transmitted Drug Resistances Among Treatment-Naive HIV-1-infected Students in Beijing, China.
作者信息
Hao Mingqiang, Wang Juan, Xin Ruolei, Li Xue, Hao Yinxiao, Chen Jing, Ye Jingrong, Wang Yu, He Xiong, Huang Chun, Lu Hongyan
机构信息
1 Chinese Center for Disease Control and Prevention , Beijing, China .
2 Institute for AIDS/STD Control and Prevention, Beijing Center for Disease Control and Prevention, Beijing Center for Preventive Medical Research , Beijing, China .
出版信息
AIDS Res Hum Retroviruses. 2017 Sep;33(9):970-976. doi: 10.1089/AID.2017.0053. Epub 2017 Apr 24.
Beijing has seen a rising epidemic of HIV among students. However, little information was known about the molecular epidemiologic data among HIV-infected students. In this study, the diversity and the prevalence of transmitted drug resistance (TDR) in pol sequences derived from 237 HIV-infected students were analyzed. TDR mutations were found in five men who have sex with men (MSM) population among students. The overall prevalence of TDR in students was 2.1%, comprising 1.3% of protease inhibitors and 0.8% of non-nucleoside reverse transcriptase inhibitors. Our finding indicates a low-level prevalence of TDR mutations among students in Beijing.
北京学生群体中的艾滋病病毒（HIV）疫情呈上升趋势。然而，关于HIV感染学生的分子流行病学数据却知之甚少。在本研究中，我们分析了237名HIV感染学生的pol基因序列中传播性耐药（TDR）的多样性和流行情况。在学生中的男男性行为者（MSM）群体中发现了5例TDR突变。学生中TDR的总体流行率为2.1%，其中蛋白酶抑制剂为1.3%，非核苷类逆转录酶抑制剂为0.8%。我们的研究结果表明，北京学生中TDR突变的流行率较低。
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