Division of Physics, Chongqing Cancer Institute & Hospital & Cancer Center, Chongqing, People's Republic of China.
Department of Radiation Oncology, Chongqing Cancer Institute & Hospital & Cancer Center, Chongqing, People's Republic of China.
Sci Rep. 2017 Mar 21;7(1):280. doi: 10.1038/s41598-017-00356-9.
Forty-nine patients with stage II cervical cancer were included to investigate the changes in bladder volume in response to different approaches to maintaining consistent bladder filling. The impacts of age (P ), water consumption (P ), and body mass index (BMI, P ) on the mean urinary inflow rate (v ) were analysed. The bladder volume (BV) increased linearly over time. A large variation in v among individuals was observed, ranging from 0.19 to 5.13 ml/min. The v was correlated with P (R = -0.53, p = 0.01) and P (R = 0.84, p = 0.00), and no correlation between v and P was found (p > 0.05). Therefore, v could be parameterized using two methods: multivariable linear regression and iterative fitting. There was no statistically significant difference between the two methods. The model accuracy was successfully assessed with several validation tests for patients with good compliance (79.2% of all patients), and the proportion of radiotherapy (RT) fractions with zero wait time (one ultrasound (US) scan) increased from 6.5% to 41.2%. The optimal US scanning number and RT time could be provided using this model. This adaptive RT approach could reduce patient discomfort caused by holding onto urine and reduce technician labour as well as cost.
纳入 49 例 II 期宫颈癌患者，以探讨不同方法维持膀胱充盈一致性时膀胱容量的变化。分析年龄（P ）、饮水量（P ）和体质量指数（BMI，P ）对平均尿流率（v ）的影响。膀胱容量（BV）随时间呈线性增加。个体间 v 的变化很大，范围为 0.19 至 5.13 ml/min。v 与 P （R = -0.53，p = 0.01）和 P （R = 0.84，p = 0.00）相关，而 v 与 P 之间无相关性（p > 0.05）。因此，v 可以使用两种方法进行参数化：多变量线性回归和迭代拟合。这两种方法之间没有统计学差异。通过对具有良好依从性的患者（所有患者的 79.2%）进行多次验证测试，成功评估了该模型的准确性，并且零等待时间（一次超声（US）扫描）的放疗（RT）分数比例从 6.5%增加到 41.2%。可以使用该模型提供最佳的超声扫描次数和 RT 时间。这种适应性 RT 方法可以减少患者憋尿引起的不适，并减少技术员的劳动和成本。
