Department of Infection Control, West China Hospital, Sichuan University, Chengdu, China.
Department of Infection Control, First People's Hospital of Beijing University, Beijing, China.
Sci Rep. 2017 Mar 21;7(1):249. doi: 10.1038/s41598-017-00302-9.
A multicenter prospective surveillance on dialysis events was carried in 33 dialysis centers in China. Maintenance hemodialysis (HD) outpatients who were dialyzed on the first two days of each month during 2014 were monitored for dialysis events and other infections. During the one-year period, 52,680 patient-months were monitored. Fistula and tunneled or non-tunneled central line were used for 73.70%, 15.70% and 8.85% of vascular access, respectively. There were 773 dialysis events occurred in 671 patients including 589 IV antimicrobial starts, 74 positive blood cultures and 110 local access site infections (LASI). The incidence of dialysis events was 1.47 per 100 patient-months. Among the 74 cases with bloodstream infection (BSI), 38 were access-related BSI (ARB) and there were therefore 148 cases with vascular-related infection (VAI; 38 ARB and 110 LASI). There were 740 cases (1.40 per 100 patient-months) with infections other than BSI and LASI, most (79.19%) of which were respiratory tract infections. For those with dialysis events, there were 425 cases (425/671, 63.34%) admitted to hospital and 12 cases of death (12/671, 1.79%). In conclusion, the surveillance revealed a relatively low incidence of dialysis events and the surveillance may be tailored to target those using central lines in resource-limited settings.
在中国 33 家透析中心进行了一项关于透析事件的多中心前瞻性监测。2014 年,每月前 2 天接受维持性血液透析(HD)的门诊患者接受透析事件和其他感染监测。在这一年期间,监测了 52680 个患者月。分别有 73.70%、15.70%和 8.85%的血管通路使用了瘘管、隧道或非隧道中央导管。在 671 名患者中发生了 773 例透析事件,包括 589 例静脉内抗菌药物起始治疗、74 例阳性血培养和 110 例局部通路部位感染(LASI)。透析事件的发生率为每 100 患者月 1.47 例。在 74 例血流感染(BSI)中,有 38 例与通路相关,因此共有 148 例与血管相关的感染(VAI;38 例与 ARB 和 110 例 LASI)。有 740 例(每 100 患者月 1.40 例)除 BSI 和 LASI 以外的感染,其中大多数(79.19%)为呼吸道感染。对于有透析事件的患者,有 425 例(425/671,63.34%)住院,12 例死亡(12/671,1.79%)。总之,监测结果显示透析事件的发生率相对较低,监测可以针对资源有限环境中使用中央导管的患者进行调整。