Bewtra C, Kable W T, Gallagher J C
Department of Pathology, Creighton University, Omaha, Nebraska.
J Reprod Med. 1988 Feb;33(2):205-8.
Thirty-six postmenopausal women were randomized to three groups in a double-blind, prospective study. All were treated for three months with conjugated estrogens (Premarin), 0.625 mg daily, and three different doses of a progestin (Provera), 2.5 mg daily, 5 mg daily or 5 mg during the last 12 days of a 28-day cycle. We found that the endometrium was maintained in an inactive phase in 100% of the women given continuous daily progestin but in only 25% of those given cyclic progestin. Bleeding occurred in 100% of subjects given cyclic progestin and in 50% of those given continuous progestin; however, bleeding episodes diminished with time in those on continuous progestin. A hormonal regimen that leads to reduced or absent bleeding and an inactive endometrium is preferable for postmenopausal women if estrogen therapy is to be used for the long term after menopause.
在一项双盲前瞻性研究中，36名绝经后女性被随机分为三组。所有女性均接受为期三个月的治疗，每天服用0.625毫克结合雌激素（普雷马林），并分别服用三种不同剂量的孕激素（安宫黄体酮），即每天2.5毫克、每天5毫克或在28天周期的最后12天服用5毫克。我们发现，在每天持续服用孕激素的女性中，100%的子宫内膜处于非活跃期，而在服用周期性孕激素的女性中，这一比例仅为25%。服用周期性孕激素的受试者中100%出现出血，服用持续孕激素的受试者中50%出现出血；然而，持续服用孕激素的女性出血情况随时间减少。如果绝经后长期使用雌激素治疗，对于绝经后女性来说，一种能减少或避免出血且使子宫内膜处于非活跃状态的激素疗法更为可取。
