额颞叶痴呆三种临床亚型中的行为和神经精神障碍：韩国痴呆临床研究中心 - 额颞叶痴呆研究
Behavioural and neuropsychiatric disturbance in three clinical subtypes of frontotemporal dementia: A Clinical Research Center for Dementia of South Korea-FTD Study.
作者信息
Park Moon Ho, Kim Eun-Joo, Park Kyung Won, Kwon Jae Cheol, Ku Bon D, Han Seol-Heui, Kim SangYun, Yang Dong Won, Na Duk L, Choi Seong Hye
机构信息
Department of Neurology, Korea University College of Medicine and Korea University Ansan Hospital, Ansan, Korea.
Department of Neurology, Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, Korea.
出版信息
Australas J Ageing. 2017 Mar;36(1):46-51. doi: 10.1111/ajag.12374.
OBJECTIVES
To characterise the behavioural and neuropsychiatric disturbances of patients with three clinical subtypes of frontotemporal dementia (FTD): behavioural variant FTD (bvFTD), semantic dementia (SD) and progressive non-fluent aphasia (PNFA).
METHODS
Consecutive series of 66 patients with bvFTD, 58 patients with SD and 21 patients with PNFA were compared using the Frontal Behavioural Inventory (FBI) and the Neuropsychiatric Inventory (NPI).
RESULTS
Patients with bvFTD had more behavioural and neuropsychiatric disturbances than patients with PNFA based on the total scores of FBI and NPI. When comparing subtotal and item scores of FBI and NPI, there were some significant differences among three clinical subtypes of FTD.
CONCLUSION
There are some distinct patterns of behavioural and neuropsychiatric disturbance among three clinical subtypes of FTD.
目的
对额颞叶痴呆（FTD）三种临床亚型的患者的行为和神经精神障碍进行特征描述，这三种亚型分别为行为变异型FTD（bvFTD）、语义性痴呆（SD）和进行性非流畅性失语（PNFA）。
方法
使用额叶行为量表（FBI）和神经精神科问卷（NPI），对连续纳入的66例bvFTD患者、58例SD患者和21例PNFA患者进行比较。
结果
基于FBI和NPI的总分，bvFTD患者比PNFA患者有更多的行为和神经精神障碍。比较FBI和NPI的分项总分及单项得分时，FTD的三种临床亚型之间存在一些显著差异。
结论
FTD的三种临床亚型之间存在一些行为和神经精神障碍的不同模式。
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