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[用于预防和控制龋齿及牙周疾病的纳米药物递送系统的研究进展]

[Research progress on a nanodrug delivery system for prevention and control of dental caries and periodontal diseases].

作者信息

Yaling Jiang, Mingye Feng, Lei Cheng

机构信息

State Key Laboratory of Oral Diseases, Dept. of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.

出版信息

Hua Xi Kou Qiang Yi Xue Za Zhi. 2017 Feb 1;35(1):104-107. doi: 10.7518/hxkq.2017.01.017.

DOI:10.7518/hxkq.2017.01.017
PMID:28326737
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7030209/
Abstract

Dental caries and periodontal diseases are common chronic infectious diseases that cause serious damage to oral health. Bacteria is the primary factor leading to such conditions. As a dental plaque control method, chemotherapeutic agents face serious challenges in dental care because of the specific physiological and anatomical characteristics of the oral cavity. Nanodrug delivery system is a series of new drug delivery systems at nanoscale, and it can target cells, promote sustainedrelease effects, and enhance biodegradation. This review focuses on research progress on nanodrug delivery systems for prevention and control of dental caries and periodontal diseases.

摘要

龋齿和牙周疾病是常见的慢性感染性疾病,会对口腔健康造成严重损害。细菌是导致这些疾病的主要因素。作为一种牙菌斑控制方法,由于口腔特定的生理和解剖学特征,化学治疗剂在牙科护理中面临严峻挑战。纳米药物递送系统是一系列纳米级的新型药物递送系统,它可以靶向细胞、促进缓释效果并增强生物降解性。本文综述聚焦于纳米药物递送系统在预防和控制龋齿及牙周疾病方面的研究进展。

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[Research progress on a nanodrug delivery system for prevention and control of dental caries and periodontal diseases].[用于预防和控制龋齿及牙周疾病的纳米药物递送系统的研究进展]
Hua Xi Kou Qiang Yi Xue Za Zhi. 2017 Feb 1;35(1):104-107. doi: 10.7518/hxkq.2017.01.017.
2
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pH-activated nanoparticles for controlled topical delivery of farnesol to disrupt oral biofilm virulence.用于将法尼醇可控局部递送以破坏口腔生物膜毒力的pH激活纳米颗粒。
ACS Nano. 2015 Mar 24;9(3):2390-404. doi: 10.1021/nn507170s. Epub 2015 Feb 13.
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Antibacterial dental composites with chlorhexidine and mesoporous silica.含氯己定和介孔二氧化硅的抗菌牙科复合材料
J Dent Res. 2014 Dec;93(12):1283-9. doi: 10.1177/0022034514555143. Epub 2014 Oct 15.
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Nanoparticle-encapsulated chlorhexidine against oral bacterial biofilms.纳米颗粒包裹的洗必泰对口腔细菌生物膜的作用
PLoS One. 2014 Aug 29;9(8):e103234. doi: 10.1371/journal.pone.0103234. eCollection 2014.
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Local delivery of minocycline-loaded PEG-PLA nanoparticles for the enhanced treatment of periodontitis in dogs.局部递送载有米诺环素的聚乙二醇-聚乳酸纳米颗粒用于增强犬牙周炎的治疗
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Triclosan-loaded poly(amido amine) dendrimer for simultaneous treatment and remineralization of human dentine.载三氯生的聚酰胺-胺树枝状高分子用于同时治疗和再矿化人牙本质。
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Hydroxyapatite-anchored dendrimer for in situ remineralization of human tooth enamel.羟基磷灰石锚定树枝状聚合物用于人牙釉质的原位再矿化。
Biomaterials. 2013 Jul;34(21):5036-47. doi: 10.1016/j.biomaterials.2013.03.053. Epub 2013 Apr 8.
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Polymer coated liposomes for dental drug delivery--interactions with parotid saliva and dental enamel.用于牙科药物输送的聚合物包被脂质体 - 与腮腺唾液和牙釉质的相互作用。
Eur J Pharm Sci. 2013 Sep 27;50(1):78-85. doi: 10.1016/j.ejps.2013.03.004. Epub 2013 Mar 20.
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Novel dental composites reinforced with zirconia-silica ceramic nanofibers.新型牙科复合材料,采用氧化锆-硅陶瓷纳米纤维增强。
Dent Mater. 2012 Apr;28(4):360-8. doi: 10.1016/j.dental.2011.11.006. Epub 2011 Dec 6.
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The impact of dendrimer-grafted modifications to model silicon surfaces on protein adsorption and bacterial adhesion.树枝状聚合物接枝修饰模型硅表面对蛋白质吸附和细菌黏附的影响。
Biomaterials. 2011 Dec;32(35):9168-79. doi: 10.1016/j.biomaterials.2011.08.063. Epub 2011 Sep 8.
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A novel spatially designed and functionally graded electrospun membrane for periodontal regeneration.一种新型空间设计和功能梯度电纺膜用于牙周再生。
Acta Biomater. 2011 Jan;7(1):216-24. doi: 10.1016/j.actbio.2010.08.019. Epub 2010 Aug 27.