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4-10厘米肾细胞癌的外科治疗:狮与羚羊的调查

Surgical Treatment of 4-10 cm Renal-Cell Carcinoma: A Survey of the Lions and Gazelles.

作者信息

Best Sara L, Blute Michael, Lane Brian, Abel E Jason

机构信息

1 Department of Urology, William S. Memorial Veterans Hospital , Madison, Wisconsin.

2 Department of Urology, University of Wisconsin School of Medicine and Public Health , Madison, Wisconsin.

出版信息

J Endourol. 2017 Apr;31(S1):S43-S47. doi: 10.1089/end.2016.0559. Epub 2017 Mar 22.

Abstract

INTRODUCTION

The decision between partial nephrectomy (PN) and radical nephrectomy (RN) may be influenced by training, practice type, or location. We sought to evaluate current opinions about the optimal management of 4-10 cm renal-cell carcinoma (RCC).

MATERIALS AND METHODS

A survey was emailed to ∼2500 Endourologic Society and Society of Urologic Oncology members regarding training, practice setting, and interest in clinical trials in addition to questions about four patient scenarios. We evaluated the associations of demographic variables with specific answers.

RESULTS

399 physicians completed the survey with 37% and 34% completing urologic oncology and endourology fellowships, respectively. More respondents reported receiving adequate training in complex open PN compared with complex minimally invasive surgery (MIS) PN, 81% vs 37%. Eighty-three percent of respondents would offer a healthy patient a PN for a 7 cm exophytic mass. Receiving adequate training in complex PN is predictive of offering PN for a central RCC (p = 0.001). Academic practitioners were more likely to offer PN in these patients (p = 0.03). Those completing training after 2000 were more likely to offer MIS (p = 0.02), and respondents who completed an oncology fellowship were more likely to offer PN to unhealthy patients (p = 0.03).

CONCLUSIONS

Opinions about the best treatment for 4-10 cm RCC differ significantly, with 70% of respondents willing to enroll patients in a randomized clinical trial. Effective efforts in teaching PN and minimally-invasive surgery result in practices that favor these approaches.

摘要

引言

部分肾切除术(PN)和根治性肾切除术(RN)之间的决策可能会受到培训、执业类型或地点的影响。我们试图评估目前对于4-10厘米肾细胞癌(RCC)最佳治疗管理的观点。

材料与方法

除了关于四种患者情况的问题外,还通过电子邮件向约2500名腔内泌尿外科协会和泌尿外科肿瘤学会成员进行了一项调查,内容涉及培训、执业环境以及对临床试验的兴趣。我们评估了人口统计学变量与具体答案之间的关联。

结果

399名医生完成了调查,分别有37%和34%的医生完成了泌尿外科肿瘤学和腔内泌尿外科进修。与复杂的微创PN相比,更多的受访者表示接受过复杂开放性PN的充分培训,分别为81%和37%。83%的受访者会为健康患者提供PN以治疗7厘米的外生性肿块。接受复杂PN的充分培训可预测为中心性RCC提供PN(p = 0.001)。学术从业者在这些患者中更倾向于提供PN(p = 0.03)。2000年后完成培训的人更倾向于提供微创手术(p = 0.02),完成肿瘤学进修的受访者更倾向于为不健康患者提供PN(p = 0.03)。

结论

对于4-10厘米RCC的最佳治疗意见存在显著差异,70%的受访者愿意让患者参加随机临床试验。在PN和微创手术教学方面的有效努力导致了倾向于这些方法的实践。

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