癌症干细胞标志物基因CD133的多态性与胃癌的易感性和预后相关。
Polymorphisms of cancer stem cell marker gene CD133 are associated with susceptibility and prognosis of gastric cancer.
作者信息
Jia Zhi-Fang, Wu Yan-Hua, Cao Dong-Hui, Cao Xue-Yuan, Jiang Jing, Zhou Bao-Sen
机构信息
Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110112, PR China.
Division of Clinical Research, First Hospital of Jilin University, Changchun 130021, PR China.
出版信息
Future Oncol. 2017 May;13(11):979-989. doi: 10.2217/fon-2017-0019. Epub 2017 Feb 24.
AIM
This study was aimed to investigate the associations between single nucleotide polymorphisms of cancer stem cell marker genes, CD44 and CD133, and susceptibility and prognosis of gastric cancer.
PATIENTS & METHODS: Five single nucleotide polymorphisms in CD44 and CD133 genes were genotyped in 898 gastric cancer cases and 992 controls.
RESULTS
The A/C or C/C genotypes of CD133 rs2240688 were associated with decreased risk of gastric cancer comparing with the A/A genotype (odds ratio: 0.81; 95% CI: 0.67-0.97; p = 0.023). The T allele of CD133 rs3130 predicted a worse survival for gastric cancer patients receiving tumorectomy (hazard ratio: 1.28; 95% CI: 1.04-1.58; p = 0.020), independent from tumor node metastasis stage, vessel invasion and postoperational chemotherapy.
CONCLUSION
CD133 polymorphisms are promising biomarkers for genetic susceptibility and prognosis prediction of gastric cancer.
目的
本研究旨在探讨癌症干细胞标志物基因CD44和CD133的单核苷酸多态性与胃癌易感性及预后之间的关联。
患者与方法
对898例胃癌病例和992例对照进行CD44和CD133基因的5个单核苷酸多态性基因分型。
结果
与A/A基因型相比，CD133 rs2240688的A/C或C/C基因型与胃癌风险降低相关（优势比：0.81；95%可信区间：0.67 - 0.97；p = 0.023）。CD133 rs3130的T等位基因预测接受肿瘤切除术的胃癌患者生存较差（风险比：1.28；95%可信区间：1.04 - 1.58；p = 0.020），独立于肿瘤淋巴结转移分期、血管侵犯和术后化疗。
结论
CD133多态性是胃癌遗传易感性和预后预测的有前景的生物标志物。
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