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Short communication: Genetic association between schizophrenia and cannabis use.简短通讯：精神分裂症与大麻使用之间的遗传关联。
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精神分裂症与物质使用共病：全基因组视角

Schizophrenia and substance use comorbidity: a genome-wide perspective.

作者信息

Polimanti Renato, Agrawal Arpana, Gelernter Joel

机构信息

Department of Psychiatry, Yale School of Medicine and VA CT Healthcare Center, West Haven, CT, USA.

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.

出版信息

Genome Med. 2017 Mar 21;9(1):25. doi: 10.1186/s13073-017-0423-3.

DOI:10.1186/s13073-017-0423-3
PMID:28327175
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5359801/
Abstract

Dual diagnosis with substance use disorders (SUDs) consistently contributes to the premature mortality and increased disability observed in schizophrenia. Large genome-wide association studies are providing the information needed to investigate the genetic architecture of psychiatric disorders. Here, we discuss recent genetic investigations of dual diagnosis (i.e., schizophrenia plus a SUD) and how these findings can inform public health messages.

摘要

物质使用障碍（SUDs）与精神分裂症的双重诊断一直是导致精神分裂症患者过早死亡和残疾增加的原因。大规模全基因组关联研究正在提供调查精神疾病遗传结构所需的信息。在此，我们讨论了近期关于双重诊断（即精神分裂症加物质使用障碍）的遗传学研究，以及这些研究结果如何为公共卫生信息提供参考。