Polymer Research Centre, Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata (IISER-K), Mohanpur 741246, Kolkata, India.
Sci Rep. 2017 Mar 22;7:44857. doi: 10.1038/srep44857.
A novel library of norbornene derived helical copolymer has been synthesized through the coupling of two homopolymers via Molecular Marriage Approach. The helicity is governed by the non-covalent interactions like hydrogen bonding, π-π stacking and the influence of hydrophobic and hydrophilic motifs. The detailed characterization of the copolymer (Copoly 1) has been provided and the super structures are confirmed through dynamic light scattering (DLS), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The observed size of the aggregates was about 200 nm. The density functional theory (DFT) is favorably supported for the formation of proposed structure of Copoly 1. Circular dichroism (CD) measurement has confirmed the one handed helical structure of the copolymer. Reservoir capability of this pH responsive polymer (Copoly 1) to encapsulate anti-cancer drug doxorubicin (DOX) warrants its potential applications in the field of bio-medical sciences.
通过分子婚姻方法将两种均聚物偶联，合成了一种新型的降冰片烯衍生的螺旋共聚物库。手性由氢键、π-π堆积等非共价相互作用以及疏水性和亲水性基序的影响来控制。对共聚物（Copoly 1）进行了详细的表征，并通过动态光散射（DLS）、扫描电子显微镜（SEM）和透射电子显微镜（TEM）确认了超结构。观察到的聚集体尺寸约为 200nm。密度泛函理论（DFT）有利于支持 Copoly 1 的提出结构的形成。圆二色性（CD）测量证实了该共聚物的单手螺旋结构。这种 pH 响应聚合物（Copoly 1）对阿霉素（DOX）等抗癌药物的包封能力证明了其在生物医学科学领域的潜在应用。
