Havasi Kálmán, Domsik Péter, Kalapos Anita, McGhie Jackie S, Roos-Hesselink Jolien W, Forster Tamás, Nemes Attila
2nd Department of Medicine and Cardiology Center - Medical Faculty - Albert Szent-Györgyi Clinical Center - University of Szeged - Szeged - Hungary.
Department of Cardiology - Erasmus MC - Rotterdam - The Netherlands.
Arq Bras Cardiol. 2017 Feb;108(2):129-134. doi: 10.5935/abc.20170004. Epub 2017 Feb 13.
Three-dimensional (3D) echocardiography coupled with speckle-tracking echocardiographic (STE) capability is a novel methodology which has been demontrated to be useful for the assessment of left atrial (LA) volumes and functional properties. There is increased scientific interest on myocardial deformation analysis in adult patients with corrected tetralogy of Fallot (cTOF).
To compare LA volumes, volume-based functional properties and strain parameters between cTOF patients and age- and gender-matched healthy controls.
The study population consisted of 19 consecutive adult patients with cTOF in sinus rhythm nursing at the University of Szeged, Hungary (mean age: 37.9 ± 11.3 years, 8 men, who had repair at the age of 4.1 ± 2.5 years). They all had undergone standard transthoracic two-dimensional Doppler echocardiographic study extended with 3DSTE. Their results were compared to 23 age- and gender-matched healthy controls (mean age: 39.2 ± 10.6 years, 14 men).
Increased LA volumes and reduced LA emptying fractions respecting cardiac cycle could be demonstrated in cTOF patients compared to controls. LA stroke volumes featuring all LA functions showed no differences between the 2 groups examined. LA global and mean segmental uni- and multidirectional peak strains featuring LA reservoir function were found to be diminished in adult patients with cTOF as compared to controls. Similarly to peak strains reduced global and mean segmental LA strains at atrial contraction characterizing atrial booster pump function could be demonstrated in cTOF patients as compared to controls.
Significant deterioration of all LA functions could be demonstrated in adult patients with cTOF late after repair.
三维（3D）超声心动图结合斑点追踪超声心动图（STE）技术是一种新型方法，已被证明可用于评估左心房（LA）容积和功能特性。在矫正型法洛四联症（cTOF）成年患者中，对心肌变形分析的科学兴趣日益增加。
比较cTOF患者与年龄和性别匹配的健康对照者之间的左心房容积、基于容积的功能特性和应变参数。
研究人群包括匈牙利塞格德大学收治的19例连续的窦性心律成年cTOF患者（平均年龄：37.9±11.3岁，8例男性，4.1±2.5岁时接受修复手术）。他们均接受了标准经胸二维多普勒超声心动图检查，并扩展了3DSTE检查。将他们的结果与23例年龄和性别匹配的健康对照者（平均年龄：39.2±10.6岁，14例男性）进行比较。
与对照组相比，cTOF患者在心动周期中左心房容积增加，左心房排空分数降低。两组间所有左心房功能的左心房每搏量无差异。与对照组相比，cTOF成年患者中具有左心房储存功能的左心房整体和平均节段单向及多向峰值应变降低。与对照组相比，cTOF患者在心房收缩时同样表现出与峰值应变类似的左心房整体和平均节段应变降低，这表征了心房辅助泵功能。
修复术后晚期的cTOF成年患者中，所有左心房功能均出现显著恶化。
