Trevisan A, Cavigli R, Stenico D, Casara D, Pasquali C, Capri C
Università di Padova, Istituto di Medicina Clinica, Ospedale Civile di Padova.
Minerva Med. 1988 Feb;79(2):81-90.
In the present work receptors for polymerized rat serum albumin (P-RSA) were studied by incubation of radiolabelled polymers with rat hepatocytes isolated with mechanical techniques. Isolated rat hepatocytes showed a receptor activity for polymerized albumin and such a membrane receptor seems to be controlled by the cellular cytoskeleton. During rat total body scintigraphy receptor expression was detected exclusively in the liver. These observations support the hypothesis of a selective receptor activity of the liver cells for polymerized albumin. To confirm our results, further studies were performed on rat bile, after 125I-P-RSA infusion in vivo.
在本研究中，通过将放射性标记的聚合物与用机械技术分离的大鼠肝细胞孵育，对聚合大鼠血清白蛋白（P-RSA）的受体进行了研究。分离出的大鼠肝细胞显示出对聚合白蛋白的受体活性，并且这种膜受体似乎受细胞骨架控制。在大鼠全身闪烁扫描期间，仅在肝脏中检测到受体表达。这些观察结果支持了肝细胞对聚合白蛋白具有选择性受体活性的假说。为了证实我们的结果，在体内注入125I-P-RSA后，对大鼠胆汁进行了进一步研究。
