Institute of Inorganic Chemistry II, University of Ulm, Albert-Einstein-Allee 11, 89081, Ulm, Germany.
Department of Functional Materials in Medicine and Dentistry and Bavarian Polymer Institute (BPI), University of Würzburg, Pleicherwall 2, 97070, Würzburg, Germany.
Angew Chem Int Ed Engl. 2017 Apr 10;56(16):4623-4628. doi: 10.1002/anie.201700153. Epub 2017 Mar 22.
The convergence of biofabrication with nanotechnology is largely unexplored but enables geometrical control of cell-biomaterial arrangement combined with controlled drug delivery and release. As a step towards integration of these two fields of research, this study demonstrates that modulation of electrostatic nanoparticle-polymer and nanoparticle-nanoparticle interactions can be used for tuning nanoparticle release kinetics from 3D printed hydrogel scaffolds. This generic strategy can be used for spatiotemporal control of the release kinetics of nanoparticulate drug vectors in biofabricated constructs.
生物制造与纳米技术的融合在很大程度上尚未得到探索，但它使细胞-生物材料排列的几何控制与受控药物输送和释放相结合成为可能。作为整合这两个研究领域的一步，本研究表明可以调节静电纳米颗粒-聚合物和纳米颗粒-纳米颗粒相互作用，从而调整 3D 打印水凝胶支架中纳米颗粒的释放动力学。这种通用策略可用于生物制造结构中纳米药物载体释放动力学的时空控制。
