Di Blasio Andrea, Izzicupo Pascal, Di Baldassarre Angela, Gallina Sabina, Bucci Ines, Giuliani Cesidio, Di Santo Serena, Di Iorio Angelo, Ripari Patrizio, Napolitano Giorgio
a Endocrine Section, Department of Medicine and Aging Sciences , "G. d'Annunzio" University of Chieti-Pescara , Chieti , Italy.
b Human Morphology Section, Department of Medicine and Aging Sciences , "G. d'Annunzio" University of Chieti-Pescara , Chieti , Italy.
Women Health. 2018 Apr;58(4):387-402. doi: 10.1080/03630242.2017.1310168. Epub 2017 Apr 18.
The literature indicates that the plasma cortisol-to-dehydroepiandrosterone-sulfate (DHEA-S) ratio is a marker of health status after menopause, when a decline in both estrogen and DHEA-S and an increase in cortisol occur. An increase in the cortisol-to-DHEA-S ratio has been positively correlated with metabolic syndrome, all-cause mortality, cancer, and other diseases. The aim of this study was to investigate the effects of a walking program on the plasma cortisol-to-DHEA-S ratio in postmenopausal women. Fifty-one postmenopausal women participated in a 13-week supervised walking program, in the metropolitan area of Pescara (Italy), from June to September 2013. Participants were evaluated in April-May and September-October of the same year. The linear mixed model showed that the variation of the logCortisol-to-logDHEA-S ratio was associated with the volume of exercise (p = .03). Participants having lower adherence to the walking program did not have a significantly modified logCortisol or logDHEA-S, while those having the highest adherence had a significant reduction in logCortisol (p = .016) and a nearly significant increase in logDHEA-S (p = .084). Walking training appeared to reduce the plasma logCortisol-to-logDHEA-S ratio, although a minimum level of training was necessary to achieve this significant reduction.
文献表明，血浆皮质醇与硫酸脱氢表雄酮（DHEA-S）的比值是绝经后健康状况的一个指标，绝经后雌激素和DHEA-S均下降，皮质醇增加。皮质醇与DHEA-S比值的升高与代谢综合征、全因死亡率、癌症及其他疾病呈正相关。本研究的目的是调查步行计划对绝经后女性血浆皮质醇与DHEA-S比值的影响。2013年6月至9月，51名绝经后女性在意大利佩斯卡拉市区参加了一项为期13周的有监督的步行计划。在同年的4月至5月以及9月至10月对参与者进行评估。线性混合模型显示，log皮质醇与log DHEA-S比值的变化与运动量相关（p = 0.03）。对步行计划依从性较低的参与者，其log皮质醇或log DHEA-S没有显著变化，而依从性最高的参与者，其log皮质醇显著降低（p = 0.016），log DHEA-S几乎显著升高（p = 0.084）。步行训练似乎降低了血浆log皮质醇与log DHEA-S的比值，不过要实现这一显著降低需要最低限度的训练量。
