Shepard J S, Pettengill O S, Wurster-Hill D H, Sorenson G D
J Natl Cancer Inst. 1979 Mar;62(3):547-54. doi: 10.1093/jnci/62.3.547.
A reproducible association between loss of tumorigenicity and specific karyotypic changes was described in cell culture lines SLU-5 and DMS-402 established from mouse plasmacytoma MOPC-21 carried in BALB/c mice. The defect in chromosome no. 15, which has been specifically associated with mouse myelomas, was neither corrected nor eliminated in the karyotypic evolution that occurred simultaneously and progressively with the grandual loss of oncogenicity.
在从携带于BALB/c小鼠体内的小鼠浆细胞瘤MOPC-21建立的细胞系SLU-5和DMS-402中，描述了致瘤性丧失与特定核型变化之间的可重复关联。与小鼠骨髓瘤特别相关的15号染色体缺陷，在与致瘤性逐渐丧失同时并逐渐发生的核型进化中，既未得到纠正也未被消除。
