Isel F, Ciesielski L, Gobaille S, Molina V, Mandel P
Centre de Neurochimie du CNRS, Strasbourg, France.
Pharmacol Biochem Behav. 1988 Jan;29(1):97-104. doi: 10.1016/0091-3057(88)90281-x.
Three groups of rats were tested for mouse killing behavior after IP injection of selective and reversible type A monoamine oxidase inhibitors. The rats were either spontaneous killers, or non-killers which acquired killing behavior following para-chlorophenylalanine treatment or electrolytical destruction of dorsal and median raphe nuclei. Moclobemide (para-chloro-N-(2-morpholinoethyl)-benzamide), cimoxatone (3-(4-(3-cyanophenyl-methoxy)phenyl)-5-(methoxy-methyl)-2-oxazo lid inone, MD 780515), toloxatone (5-(hydroxymethyl)-3-(3-methylphenyl)-2-oxazolidinone) and amiflamine ((+)-4-dimethylamino-2, alpha-dimethylphenethyl amine, FLA 336 (+)) were used as selective and reversible monoamine oxidase inhibitors of type A. Cimoxatone, toloxatone and amiflamine inhibited mouse killing behavior of spontaneous killer rats without apparent sedation, whereas moclobemide was not efficient at doses which did not decrease locomotor activity. A similar inhibition of mouse killing behavior was obtained in spontaneous and serotonin depleted killer rats. The results are discussed in relation to the behavioral expression of serotoninergic supersensitivity in the three groups of killer rats described earlier using serotonin agonist and uptake inhibitors.
给三组大鼠腹腔注射选择性且可逆的A型单胺氧化酶抑制剂后，测试它们的杀鼠行为。这些大鼠要么是自发杀手型，要么是在接受对氯苯丙氨酸处理或电解损毁背侧和中缝核后获得杀鼠行为的非杀手型。吗氯贝胺（对氯-N-(2-吗啉乙基)-苯甲酰胺）、西莫沙酮（3-(4-(3-氰基苯基甲氧基)phenyl)-5-(甲氧基甲基)-2-恶唑烷酮，MD 780515）、托洛沙酮（5-(羟甲基)-3-(3-甲基苯基)-2-恶唑烷酮）和阿米氟胺（(+)-4-二甲基氨基-2,α-二甲基苯乙胺，FLA 336(+)）被用作选择性且可逆的A型单胺氧化酶抑制剂。西莫沙酮、托洛沙酮和阿米氟胺抑制自发杀手型大鼠的杀鼠行为，且无明显镇静作用，而吗氯贝胺在不降低运动活性的剂量下无效。在自发杀手型和血清素耗竭的杀手型大鼠中也获得了类似的对杀鼠行为的抑制。结合先前使用血清素激动剂和摄取抑制剂描述的三组杀手型大鼠中血清素能超敏反应的行为表现，对结果进行了讨论。
