Ozdemir Ahmet, Gunes Tamer, Chiang Samuel C C, Unal Ekrem
*Department of Pediatrics, Division of Neonatalogy ‡Department of Pediatrics, Division of Pediatric Hematology-Oncology, Faculty of Medicine, Erciyes University, Kayseri, Turkey †Department of Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
J Pediatr Hematol Oncol. 2017 Aug;39(6):e309-e311. doi: 10.1097/MPH.0000000000000777.
Hemophagocytic lymphohistiocytosis (HLH) is characterized by activation of cytotoxic T and natural killer (NK) cells, and macrophages related to a spectrum of hyperinflammatory disorders. The clinical findings mainly include high fever, cytopenia, splenomegaly, phagocytosis, and proliferation of histiocytes in lymphoreticular tissue. To the best of our knowledge, transfusion-associated graft versus host disease (TA-GVHD) in a 13-day old male newborn with HLH is being reported first time in the literature. The aim of this report was to emphasize the importance of blood products irradiation in the prevention of the development of graft versus host disease especially among high-risk subjects such as newborns with HLH.
