Narala Saisindhu, Cohen Philip R
School of Medicine, University of California San Diego.
Dermatol Online J. 2017 Jan 15;23(1):13030/qt0w01b1t3.
The sign of Leser-Trélat is characterizedby the sudden appearance of seborrheic keratosesassociated with an underlying malignancy.
An elderly man who developed multiple new-onsetseborrheic keratoses temporally associated witha diagnosis of mycosis fungoides is described andlymphoma-associated Leser-Trélat sign is reviewed.
Pubmed was used to search the followingterms: cutaneous T-cell lymphoma, Leser-Trélat,leukemia, lymphoma, mycosis fungoides, and Sézarysyndrome. Papers with these terms and referencescited within these papers were reviewed.
An 84-year-old man developed multiple seborrheickeratoses temporally associated with a diagnosisof mycosis fungoides is presented. He was treatedwith bexarotene and achieved clinical remission;the number of seborrheic keratoses also decreased.Lymphoma-associated Leser-Trélat sign has beenobserved not only with mycosis fungoides but alsoother lymphomas and leukemias.
Thesign of Leser-Trélat is predominantly associated withsolid organ adenocarcinomas. Albeit less common, aneruptive onset of seborrheic keratoses can also occurin association with hematopoietic malignancies.
Leser-Trélat征的特征是脂溢性角化病突然出现并伴有潜在恶性肿瘤。
描述一名老年男性，其出现多个新发脂溢性角化病，时间上与蕈样肉芽肿的诊断相关，并对淋巴瘤相关的Leser-Trélat征进行综述。
使用PubMed搜索以下术语：皮肤T细胞淋巴瘤、Leser-Trélat征、白血病、淋巴瘤、蕈样肉芽肿和Sezary综合征。对包含这些术语的论文以及这些论文中引用的参考文献进行综述。
报告了一名84岁男性，其出现多个脂溢性角化病，时间上与蕈样肉芽肿的诊断相关。他接受了贝沙罗汀治疗并实现临床缓解；脂溢性角化病的数量也减少了。不仅在蕈样肉芽肿中观察到淋巴瘤相关的Leser-Trélat征，在其他淋巴瘤和白血病中也有观察到。
Leser-Trélat征主要与实体器官腺癌相关。尽管不太常见，但脂溢性角化病的爆发性发作也可与造血系统恶性肿瘤相关。
