Haddock Ellen S, Cohen Philip R
School of Medicine, University of California San Diego, San Diego, California.
Dermatol Online J. 2016 Nov 15;22(11):13030/qt9n4377w6.
Background Topical 5-fluorouracil (5-FU) is an antineoplastic antimetabolite used for the treatment of actinic keratosis.Purpose A 66-year-old man with erythematotelangiectatic rosacea and biopsy-confirmed actinic keratoses who experienced a rosacea exacerbation after initiating topical 5-FU treatment of his actinic keratoses is described and this adverse event associated with 5-FU is reviewed.Materials and methods Using PubMed.gov the following terms were searched and relevant citations were assessed: rosacea and 5-fluorouracil. 5-FU drug label information and data sheets also were reviewed.ResultsErythematous facial papules developed within a week of starting topical treatment of his actinic keratoses with 5-FU. The lesions resolved within two weeks of discontinuing the medication. Albeit rarely, exacerbation of rosacea by topical 5-FU treatment has been described when 5-FU was introduced as a topical treatment for actinic keratosis.Conclusion Topical 5-FU has been associated with several adverse cutaneous events, including accentuation of rosacea. Although rosacea flares due to topical 5-FU may be uncommon, the incidence may be greater than reflected in the literature. Physicians should be aware of this potential adverse effect in patients in whom they plan to initiate 5-FU therapy.
背景 外用5-氟尿嘧啶（5-FU）是一种用于治疗光化性角化病的抗肿瘤抗代谢物。
目的 描述一名66岁患有红斑毛细血管扩张性酒渣鼻且活检确诊为光化性角化病的男性，其在开始外用5-FU治疗光化性角化病后出现酒渣鼻加重的情况，并对这种与5-FU相关的不良事件进行综述。
材料和方法 通过PubMed.gov搜索以下术语并评估相关文献：酒渣鼻和5-氟尿嘧啶。还查阅了5-FU药品标签信息和数据表。
结果 在开始用5-FU外用治疗光化性角化病一周内出现面部红斑丘疹。停药后两周内病变消退。尽管很少见，但当5-FU作为光化性角化病的外用治疗药物引入时，外用5-FU治疗导致酒渣鼻加重的情况已有描述。
结论 外用5-FU与多种皮肤不良事件有关，包括酒渣鼻加重。虽然外用5-FU引起的酒渣鼻发作可能不常见，但实际发生率可能高于文献报道。医生在计划对患者启动5-FU治疗时应意识到这种潜在的不良反应。
