Host-Toxoplasma Interaction Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Host-Toxoplasma Interaction Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Trends Parasitol. 2017 Jun;33(6):473-488. doi: 10.1016/j.pt.2017.02.007. Epub 2017 Mar 19.
The parasitophorous vacuole is a unique replicative niche for apicomplexan parasites, including Toxoplasma gondii. Derived from host plasma membrane, the vacuole is rendered nonfusogenic with the host endolysosomal system. Toxoplasma secretes numerous proteins to modify the forming vacuole, enable nutrient uptake, and set up mechanisms of host subversion. Here we describe the pathways of host-parasite interaction at the parasitophorous vacuole employed by Toxoplasma and host, leading to the intricate balance of host defence versus parasite survival.
滋养体空泡是顶复门寄生虫（包括刚地弓形虫）独特的复制小生境。该空泡来源于宿主质膜，且与宿主内体溶酶体系统不融合。刚地弓形虫分泌大量蛋白来修饰正在形成的空泡，以促进营养摄取并建立宿主颠覆机制。本文将描述刚地弓形虫和宿主在滋养体空泡上的相互作用途径，导致宿主防御与寄生虫存活之间的复杂平衡。
