Tverskoy M, Fleyshman G, Bradley E L, Kissin I
Department of Anesthesiology, Rebecca Sieff Government Hospital, Safed, Israel.
Anesth Analg. 1988 Apr;67(4):342-5.
The effect of thiopental on the induction dose-response curve for midazolam was studied in nonpremedicated ASA physical status I and II patients. As an endpoint of anesthesia, ability to open eyes on command was used. Dose-response curves for thiopental, midazolam, and their combination were determined with a probit procedure and compared with an isobolographic analysis. Interaction between midazolam and thiopental was found to be synergistic (supraadditive). The degree of midazolam-thiopental anesthetic synergism in surgical patients was close to that reported previously in rats with loss of the righting reflex as an index of anesthesia.
在未进行术前用药的美国麻醉医师协会（ASA）身体状况为I级和II级的患者中，研究了硫喷妥钠对咪达唑仑诱导剂量-反应曲线的影响。作为麻醉终点，采用按指令睁眼的能力。用概率单位法确定硫喷妥钠、咪达唑仑及其组合的剂量-反应曲线，并与等效线图分析进行比较。发现咪达唑仑和硫喷妥钠之间的相互作用是协同的（超相加）。手术患者中咪达唑仑-硫喷妥钠麻醉协同程度与先前报道的以翻正反射消失为麻醉指标的大鼠中的情况相近。
