Roytblat L, Katz J, Rozentsveig V, Gesztes T, Bradley E L, Kissin I
Department of Anaesthesiology, Soroka Medical Centre, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Eur J Anaesthesiol. 1992 Jul;9(4):307-12.
The anaesthetic effect of thiopentone, ketamine and their combinations were studied in 150 patients of ASA Grades I and II. The ability to open eyes on command and purposeful motor response to noxious pressure on the trapezius muscle were used as endpoints of anaesthesia. Dose-response curves for thiopentone, ketamine and their combinations were determined with a probit procedure and compared with isobolographic analysis. The interaction between thiopentone and ketamine was found to be additive for both endpoints of anaesthesia.
