(-)- 垂瓣石松 A 的非对映体全合成。
Asymmetric Total Synthesis of (-)-Aspidophylline A.
机构信息
The State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University , Lanzhou 730000, China.
Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University , Shenzhen 518055, China.
出版信息
Org Lett. 2017 Apr 7;19(7):1650-1653. doi: 10.1021/acs.orglett.7b00448. Epub 2017 Mar 23.
An asymmetric total synthesis of (-)-aspidophylline A has been accomplished. The key transformations include an asymmetric hydride transfer hydrogenation of an α,β-acetylenic ketone and a cationic gold(I)-catalyzed 6-exo-dig cyclization involving an alkynylindole/aminal formation cascade, which enables stereoselective establishment of the requisite quaternary carbon center.
已完成 (-)-aspidophylline A 的不对称全合成。关键转化包括α,β-炔基酮的不对称氢转移氢化和涉及炔基吲哚/亚胺形成级联的阳离子金（I）催化的 6-endo-dig 环化反应，这使得所需的季碳原子的立体选择性建立成为可能。
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