5'-Nucleotidase in skin fibroblasts from patients with Duchenne muscular dystrophy.
作者信息
Sinclair C E, Ecob-Prince M S, Pennington R J
机构信息
Department of Neurochemistry, Newcastle General Hospital, Newcastle upon Tyne, England.
出版信息
Biochem Med Metab Biol. 1988 Feb;39(1):1-4. doi: 10.1016/0885-4505(88)90050-3.
PMID:2833294
Abstract
The 5'-nucleotidase of plasma membranes of cultured skin fibroblasts from patients with Duchenne muscular dystrophy had a reduced affinity for its substrate, 5'-AMP. The Arrhenius plot of the temperature dependence of this enzyme activity was normal. There was no difference between patients and controls in the specific 5'-nucleotidase activity in the whole cell homogenates.
摘要
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