惊恐障碍患者的正常尿游离皮质醇和血浆 3-甲氧基-4-羟基苯乙二醇：临床及理论意义

Normal urinary free cortisol and plasma MHPG in panic disorder: clinical and theoretical implications.

作者信息

Uhde T W, Joffe R T, Jimerson D C, Post R M

机构信息

Unit of Anxiety and Affective Disorders, NIMH, Bethesda, MD 20892.

出版信息

Biol Psychiatry. 1988 Mar 15;23(6):575-85. doi: 10.1016/0006-3223(88)90004-2.

DOI:10.1016/0006-3223(88)90004-2

PMID:2833321

Abstract

Abnormalities of the hypothalamic-pituitary-adrenal (HPA) axis and noradrenergic function have been reported in patients with panic disorder. Mean urinary free cortisol and plasma MHPG were measured in 12 medication-free panic disorder patients and 12 normal controls. No significant difference in urinary free cortisol and plasma MHPG was observed between the patients and controls. There was no relationship between plasma MHPG and urinary free cortisol in the panic patients or normal controls. These findings are described within the context of current concepts of stress and noradrenergic dysfunction in panic disorder.

摘要

惊恐障碍患者中已报道存在下丘脑 - 垂体 - 肾上腺（HPA）轴和去甲肾上腺素能功能异常。对12名未服用药物的惊恐障碍患者和12名正常对照者测量了尿游离皮质醇均值和血浆3 - 甲氧基 - 4 - 羟基苯乙二醇（MHPG）。患者与对照者之间在尿游离皮质醇和血浆MHPG方面未观察到显著差异。惊恐障碍患者或正常对照者的血浆MHPG与尿游离皮质醇之间无相关性。这些发现是在惊恐障碍中应激和去甲肾上腺素能功能障碍的当前概念背景下进行描述的。