Prihadi Edgard A, Delgado Victoria, Bax Jeroen J
Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands -
Minerva Cardioangiol. 2017 Oct;65(5):516-530. doi: 10.23736/S0026-4725.17.04378-X. Epub 2017 Mar 23.
Tricuspid regurgitation (TR) is a highly prevalent valvular heart disease. The natural history of untreated significant TR portends an unfavorable outcome, but only a minority of patients is currently referred for surgical treatment. Organic TR (caused by primary abnormality of the leaflets) is relatively infrequent whereas secondary or functional TR (caused by dilatation of the tricuspid annulus, right ventricle [RV] and right atrium) is the predominant mechanism. The success of transcatheter therapies for left valvular heart disease over the last decade, has fueled similar development of novel transcatheter devices for the treatment of TR. Currently being tested in several clinical trials, each of these devices requires specific needs to define the procedural suitability. In addition, an accurate evaluation of the complex tricuspid anatomy, RV geometry and their relationship with the surrounding structures is mandatory. Therefore, accurate pre-procedural assessment using multimodality imaging techniques will undoubtedly play a pivotal role in achieving procedural success and safety. This review article provides a comprehensive overview on the etiology and different mechanisms of TR, and highlights the role of multimodality imaging techniques in the assessment of TR severity, RV dysfunction and fulfilment of device-specific selection criteria.
三尖瓣反流(TR)是一种非常常见的心脏瓣膜疾病。未经治疗的严重TR的自然病程预示着不良后果,但目前只有少数患者被转诊接受手术治疗。器质性TR(由瓣叶原发性异常引起)相对少见,而继发性或功能性TR(由三尖瓣环、右心室[RV]和右心房扩张引起)是主要机制。过去十年中经导管治疗左心瓣膜疾病的成功推动了用于治疗TR的新型经导管装置的类似发展。目前这些装置正在多项临床试验中进行测试,每种装置都需要特定条件来确定手术适用性。此外,对复杂的三尖瓣解剖结构、RV几何形状及其与周围结构的关系进行准确评估是必不可少的。因此,使用多模态成像技术进行准确的术前评估无疑将在实现手术成功和安全方面发挥关键作用。这篇综述文章全面概述了TR的病因和不同机制,并强调了多模态成像技术在评估TR严重程度、RV功能障碍以及满足特定装置选择标准方面的作用。