Peterson B, Bezuidenhout C C, Van den Berg J
Potchefstroom Campus, North-West University, Potchefstroom, 2531, South Africa (
J Econ Entomol. 2017 Apr 1;110(2):362-377. doi: 10.1093/jee/tow310.
Arthropods have the capacity to evolve resistance to insecticides and insecticidal traits in genetically modified crops. Resistance development among Lepidoptera is a common phenomenon, and a repertoire of resistance mechanisms to various Cry toxins have been identified from laboratory, greenhouse, and field studies in this insect order. Elucidation of such resistance mechanisms is crucial for developing IRM (insect resistance management) strategies to ensure sustainable use of genetically modified crops. This mini review provides a comprehensive overview of mechanisms of resistance that have been reported for lepidopteran pests. This study demonstrated that resistance mechanisms are highly complex, and the most common mechanism of resistance is altered binding sites. It is yet to be established whether all these altered binding sites are regulated by an MAPK signaling pathway, which might suggest a universal mechanism of resistance in lepidopterans.
节肢动物有能力进化出对杀虫剂和转基因作物中杀虫性状的抗性。鳞翅目昆虫中抗性的发展是一种常见现象，并且已经从该昆虫目的实验室、温室和田间研究中鉴定出了对各种Cry毒素的一系列抗性机制。阐明这些抗性机制对于制定害虫抗性管理（IRM）策略以确保转基因作物的可持续利用至关重要。本综述对已报道的鳞翅目害虫抗性机制进行了全面概述。这项研究表明抗性机制非常复杂，最常见的抗性机制是结合位点改变。所有这些改变的结合位点是否都由丝裂原活化蛋白激酶（MAPK）信号通路调控尚待确定，这可能暗示了鳞翅目昆虫抗性的一种普遍机制。
