S K Raksha, Dakshayani B, R Premalatha
Department of Pediatrics, Bangalore Medical College and Research institute, Bangalore 560079, India.
J Trop Pediatr. 2017 Dec 1;63(6):454-460. doi: 10.1093/tropej/fmx012.
We aimed to compare the effect of two different intravenous fluid regimes on the incidence of hyponatremia in children.
Children 1 month to 18 years of age, admitted to pediatric intensive care unit (PICU) of a tertiary care medical college hospital were randomized to receive either isotonic fluid (0.9% saline in 5% dextrose) at the standard maintenance rate or hypotonic fluid (0.18% saline in 5% dextrose) at two-thirds of the standard maintenance rate.
A total of 240 children were randomized (120 isotonic, 120 hypotonic). In all, 16.7% children in hypotonic group developed hyponatremia compared with 7.5% in isotonic group (p = 0.029). Duration of PICU stay was significantly more in Hypotonic group.
We conclude that use of 0.9% saline in 5% dextrose as maintenance fluid helps in reducing the incidence of hospital-acquired hyponatremia and duration of intensive care unit stay among children admitted to PICU.
我们旨在比较两种不同静脉输液方案对儿童低钠血症发生率的影响。
将入住三级医疗学院医院儿科重症监护病房（PICU）的1个月至18岁儿童随机分为两组，一组按标准维持速率接受等渗液（5%葡萄糖加0.9%生理盐水），另一组按标准维持速率的三分之二接受低渗液（5%葡萄糖加0.18%生理盐水）。
共有240名儿童被随机分组（120名接受等渗液，120名接受低渗液）。总体而言，低渗液组16.7%的儿童发生了低钠血症，而等渗液组为7.5%（p = 0.029）。低渗液组在PICU的住院时间明显更长。
我们得出结论，使用5%葡萄糖加0.9%生理盐水作为维持液有助于降低入住PICU儿童医院获得性低钠血症的发生率以及重症监护病房的住院时间。
