Featherstone N C, Somani B K, Griffin S J
Department of Paediatric Urology, University Hospital Southampton NHS Trust, Tremona Road, Southampton, UK.
Department of Urology, University Hospital Southampton NHS Trust, Tremona Road, Southampton, UK.
J Pediatr Urol. 2017 Apr;13(2):202.e1-202.e7. doi: 10.1016/j.jpurol.2016.07.006. Epub 2016 Aug 24.
The treatment of large renal stones (≥1 cm) in paediatric patients is challenging. The usual treatment options include percutaneous nephrolithotomy (PCNL) or shockwave lithotripsy (SWL). There is a rise in the use of ureteroscopy and laser stone fragmentation (URSL) for paediatric stones; however, outcomes of treatment for large renal stones in this age group are still largely unknown.
To investigate the outcome of URSL for large paediatric renal stones ≥1 cm treated at the present institution over the last 5 years.
A retrospective review was performed of outcomes from the prospectively maintained stone database. Only paediatric patients undergoing ureteroscopic (rigid or flexible ureteroscopy (URS)) procedures for stones ≥1 cm were included. Patient demographics, operative details, stone burden, hospital stay, complications and stone clearance were recorded and analysed.
From April 2010 to June 2015, 18 paediatric patients with a mean age of 10.4 years (range 3.6-15) underwent 35 ureteroscopic procedures for large stones (≥1 cm). The stone location was in the kidney (n = 14), ureter (n = 1), and in both the kidney and ureter for the remaining three patients. Nine patients had multiple stones. There was a preceding history of PCNL in four patients, with one patient having URS combined with a PCNL. The mean follow-up was 2.7 years (range 0-5). A postoperative stent was inserted in 21 (60%) patients. The overall stone-free rate (SFR) was 89% for a mean of 1.8 procedures per patient (range 1-4) - see Summary Table below. There was an inability to access stone within a lower pole calyx in one patient, despite maximum deflection of the ureteroscope. No intra- or post-operative complications were noted, and mean hospital stay was 1.1 days (range 0-5).
Published papers in adult literature have shown that ureteroscopy and laser fragmentation (URSL) is a viable alternative to PCNL. Newer equipment and improved techniques have resulted in SFRs being comparable with PCNL. A recent systematic review reported an SFR of 91% for large adult stones (>2 cm) for a mean 1.45 procedures per patient, and an overall complication rate of 8.6%. The present study has also demonstrated excellent outcomes in the use of ureteroscopy and laser fragmentation for the management of large paediatric stones with no complications.
The results show that paediatric URSL for large stones achieves a good SFR with minimal morbidity and is a good treatment option in established endourological units.
小儿患者大肾结石(≥1厘米)的治疗具有挑战性。常用的治疗选择包括经皮肾镜取石术(PCNL)或冲击波碎石术(SWL)。输尿管镜检查和激光碎石术(URSL)在小儿结石治疗中的应用有所增加;然而,该年龄组大肾结石的治疗结果仍大多未知。
研究过去5年在本机构接受治疗的≥1厘米小儿大肾结石的URSL治疗结果。
对前瞻性维护的结石数据库的结果进行回顾性分析。仅纳入接受输尿管镜(硬性或软性输尿管镜(URS))治疗≥1厘米结石的小儿患者。记录并分析患者的人口统计学资料、手术细节、结石负荷、住院时间、并发症和结石清除情况。
2010年4月至2015年6月,18例平均年龄为10.4岁(范围3.6 - 15岁)的小儿患者接受了35次输尿管镜治疗大结石(≥1厘米)的手术。结石位于肾脏(n = 14)、输尿管(n = 1),其余3例患者结石位于肾脏和输尿管。9例患者有多颗结石。4例患者有PCNL病史,1例患者接受了URS联合PCNL治疗。平均随访时间为2.7年(范围0 - 5年)。21例(60%)患者术后插入了支架。总体无石率(SFR)为89%,每位患者平均手术1.8次(范围1 - 4次) - 见下表总结。尽管输尿管镜最大限度地偏转,但1例患者仍无法进入下极肾盏的结石。未观察到术中或术后并发症,平均住院时间为1.1天(范围0 - 5天)。
成人文献发表的论文表明,输尿管镜检查和激光碎石术(URSL)是PCNL的可行替代方法。更新的设备和改进的技术使无石率与PCNL相当。最近一项系统评价报告,成人>2厘米大结石的无石率为91%,每位患者平均手术1.45次,总体并发症发生率为8.6%。本研究也证明了输尿管镜检查和激光碎石术在治疗小儿大结石方面取得了良好的效果,且无并发症。
结果表明,小儿大结石的URSL治疗可实现良好的无石率,发病率极低,是成熟的腔内泌尿外科单位的良好治疗选择。