Ishikawa T, Tanaka Y, Sugihara K, Hatano M, Kaneko A, Motoji K, Nasu M, Okayasu I, Sato T, Inaba N
Dept. of Obstet. & Gynecol., Kudanzaka Hospital.
Gan No Rinsho. 1988 Mar;34(3):277-82.
The tissue distribution of CA 15-3, a breast carcinoma associated antigenic determinant, has been investigated by an avidin-biotin immunoperoxidase technique in the human breasts and in their tumors. In cases of scirrhous carcinoma, positive stainings for CA 15-3 were observed in almost all carcinoma cells. In cases of solid-tubular carcinomas and papillotubular carcinomas, the reaction was various and there was no correlation between the distribution of CA 15-3 and the clinical stage. Apical staining was recognized in both solid-tubular and papillotubular carcinomas, in benign breast tumors, and in normal breast tissues. CA 15-3 appears to be related to the degree of differentiation of the breast tissue.
采用抗生物素蛋白-生物素免疫过氧化物酶技术，对人乳腺及其肿瘤中乳腺癌相关抗原决定簇CA 15-3的组织分布进行了研究。在硬癌病例中，几乎所有癌细胞均观察到CA 15-3阳性染色。在实体管状癌和乳头管状癌病例中，反应各异，且CA 15-3的分布与临床分期之间无相关性。在实体管状癌和乳头管状癌、良性乳腺肿瘤及正常乳腺组织中均观察到顶端染色。CA 15-3似乎与乳腺组织的分化程度有关。
