2016年年中日本儿童肠胃炎疫情期间诺如病毒GII.2的出现及其新型重组情况。
Emergence of norovirus GII.2 and its novel recombination during the gastroenteritis outbreak in Japanese children in mid-2016.
作者信息
Thongprachum Aksara, Okitsu Shoko, Khamrin Pattara, Maneekarn Niwat, Hayakawa Satoshi, Ushijima Hiroshi
机构信息
Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan.
Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan; Department of Developmental Medical Sciences, School of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
出版信息
Infect Genet Evol. 2017 Jul;51:86-88. doi: 10.1016/j.meegid.2017.03.020. Epub 2017 Mar 20.
In mid-2016, norovirus GII.2 emerged as a major cause of gastroenteritis outbreak in Japan with overall detection rate of 56.3% of norovirus cases. The differences in ORF1 and ORF2 of some norovirus GII were observed. Inter-subtype recombinants GII.Pe/GII.2, GII.P16/GII.2 and GII.P17/GII.2 were detected. Three amino acid substitutions were noted at P2 antigenic site of GII.P16/GII.2 recombinants. Furthermore, this study revealed that the current immunochromatographic kit available in Japan could be used effectively for the detection of recent GII.2 genotype.
2016年年中，诺如病毒GII.2成为日本肠胃炎暴发的主要病因，在诺如病毒病例中的总体检出率为56.3%。观察到一些GII型诺如病毒的ORF1和ORF2存在差异。检测到亚型间重组体GII.Pe/GII.2、GII.P16/GII.2和GII.P17/GII.2。在GII.P16/GII.2重组体的P2抗原位点发现了三个氨基酸替换。此外，本研究表明，日本目前可用的免疫层析试剂盒可有效用于检测近期的GII.2基因型。
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