无论糖尿病状态如何，重度肥胖患者胃主细胞中GLP2R表达均增加。
Increased GLP2R expression in gastric chief cells of patients with severe obesity regardless of diabetes status.
作者信息
Li F, Lu L, Peng Y, Zhang Y, Gao J, Zhou D, Zhou D, Sheng H, Qu S
机构信息
Department of Endocrinology and Metabolism, National Metabolic Management Center, Shanghai Tenth People's Hospital, Tong-Ji University, Shanghai 200072, China.
Department of General Surgery, National Metabolic Management Center, Shanghai Tenth People's Hospital, Tong-Ji University, Shanghai, China.
出版信息
Int J Obes (Lond). 2017 Aug;41(8):1303-1305. doi: 10.1038/ijo.2017.77. Epub 2017 Mar 24.
Glucagon-like peptide-2 (GLP-2) affects multiple facets of gastrointestinal physiology and have been used to treat patients with short bowel syndrome, but the distribution of its receptor (GLP2R) in human remains poorly understood. Gastric tissue samples of non-obese patients (NOB, n=10) and obese patients without diabetes (OB, n=31) and with diabetes (OWD, n=12) were used to evaluate GLP2R expression and distribution. Immunostaining with a validated antibody, as well as fluorescence in situ hybridization, showed that GLP2R expression was significantly increased in gastric chief cells in OB and OWD patients. PKCζ expression was also significantly increased. This is the first evidence of increased GLP2R expression in chief cells of patients with severe obesity regardless of diabetes status.
胰高血糖素样肽-2（GLP-2）影响胃肠道生理的多个方面，并已被用于治疗短肠综合征患者，但其受体（GLP2R）在人体内的分布仍知之甚少。使用非肥胖患者（NOB，n = 10）、无糖尿病肥胖患者（OB，n = 31）和糖尿病肥胖患者（OWD，n = 12）的胃组织样本评估GLP2R的表达和分布。使用经过验证的抗体进行免疫染色以及荧光原位杂交显示，OB和OWD患者胃主细胞中的GLP2R表达显著增加。PKCζ表达也显著增加。这是重度肥胖患者主细胞中GLP2R表达增加的首个证据，无论其糖尿病状态如何。
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