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儿科抗菌药物管理计划

Pediatric Antimicrobial Stewardship Programs.

作者信息

Nichols Kristen, Stoffella Sylvia, Meyers Rachel, Girotto Jennifer

出版信息

J Pediatr Pharmacol Ther. 2017 Jan-Feb;22(1):77-80. doi: 10.5863/1551-6776-22.1.77.

Abstract

The frequent use of antimicrobials in pediatric patients has led to a significant increase in multidrug-resistant bacterial infections among children. Antimicrobial stewardship programs have been created in many hospitals in an effort to curtail and optimize the use of antibiotics. Pediatric-focused programs are necessary because of the differences in antimicrobial need and use among this patient population, unique considerations and dosing, vulnerability for resistance due to a lifetime of antibiotic exposure, and the increased risk of adverse events. This paper serves as a position statement of the Pediatric Pharmacy Advocacy Group (PPAG) who supports the implementation of antimicrobial stewardship programs for all pediatric patients. PPAG also believes that a pediatric pharmacy specialist should be included as part of that program and that services be covered by managed care organizations and government insurance entities. PPAG also recommends that states create legislation similar to that in existence in California and Missouri and that a federal Task Force for Combating Antibiotic-Resistant Bacteria be permanently established. PPAG also supports post-doctoral pharmacy training programs in antibiotic stewardship.

摘要

儿科患者中抗菌药物的频繁使用导致儿童多重耐药细菌感染显著增加。许多医院已设立抗菌药物管理项目,以减少和优化抗生素的使用。由于该患者群体在抗菌药物需求和使用方面存在差异、有独特的考量因素和剂量、因一生接触抗生素而有耐药风险以及不良事件风险增加,因此以儿科为重点的项目很有必要。本文是儿科药学倡导组织(PPAG)的立场声明,该组织支持为所有儿科患者实施抗菌药物管理项目。PPAG还认为,儿科药学专家应作为该项目的一部分,且相关服务应由管理式医疗组织和政府保险实体提供。PPAG还建议各州制定与加利福尼亚州和密苏里州类似的立法,并永久设立一个抗击抗生素耐药细菌联邦特别工作组。PPAG还支持开展抗生素管理方面的博士后药学培训项目。

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Pediatric Antimicrobial Stewardship Programs.儿科抗菌药物管理计划
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本文引用的文献

3
Making a Case for Pediatric Antimicrobial Stewardship Programs.为儿科抗菌药物管理计划提供依据
Pharmacotherapy. 2015 Nov;35(11):1026-36. doi: 10.1002/phar.1647. Epub 2015 Nov 2.
5
Neonatal intensive care unit antibiotic use.新生儿重症监护病房抗生素使用。
Pediatrics. 2015 May;135(5):826-33. doi: 10.1542/peds.2014-3409. Epub 2015 Apr 20.

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