Cháirez-Ramírez M H, Moreno-Jiménez M R, González-Laredo R F, Gallegos-Infante J A, Rocha-Guzmán Nuria Elizabeth
Instituto Tecnológico de Durango, Departamento de Ingenierías Química y Bioquímica, Blvd. Felipe Pescador 1830 Ote., Col Nueva Vizcaya, 34080 Durango, Dgo., México.
EXCLI J. 2016 Nov 30;15:758-771. doi: 10.17179/excli2016-642. eCollection 2016.
In recent times, a great deal of interest has been motivated on plant derived compounds known as nutraceuticals. These compounds exert important beneficial activities that improve people's health status when are consumed regularly, and now they appear as a viable option to explore their possible therapeutic effects against diseases like cancer. Particularly, lupane-type triterpenes have shown great ability to modulate multiple cancer-related signaling pathways and processes, including NF-κB, Wnt/β-catenin, PI3K/Akt, apoptosis, and many other routes related to proliferation or cell death, which are uncontrolled in malignant tumors. These investigations have promoted and studies, searching their mechanisms of action; although more research is still needed to prove its potential in human clinical trials. This review focuses on the ability of betulin, betulinic acid and lupeol to show benefits against the most common types of malignant tumors, which are considered a major global threat for public health.
近年来，人们对一类名为营养保健品的植物源化合物产生了浓厚兴趣。这些化合物具有重要的有益活性，定期食用可改善人们的健康状况，如今它们似乎是探索其对癌症等疾病可能的治疗作用的可行选择。特别是，羽扇豆烷型三萜已显示出强大的调节多种癌症相关信号通路和过程的能力，包括核因子κB、Wnt/β-连环蛋白、磷脂酰肌醇-3-激酶/蛋白激酶B、细胞凋亡以及许多其他与增殖或细胞死亡相关的途径，而这些途径在恶性肿瘤中是不受控制的。这些研究推动了相关研究，探索它们的作用机制；尽管仍需要更多研究来证明其在人体临床试验中的潜力。本综述重点关注桦木醇、桦木酸和羽扇豆醇对最常见类型恶性肿瘤的有益作用，这些肿瘤被认为是对公众健康的主要全球威胁。
