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Light-Regulated NO Release as a Novel Strategy To Overcome Doxorubicin Multidrug Resistance.光调控一氧化氮释放作为克服阿霉素多药耐药性的新策略。
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Near-infrared light switching nitric oxide nanoemitter for triple-combination therapy of multidrug resistant cancer.近红外光切换型一氧化氮纳米发射器用于多药耐药性癌症的三联组合治疗。
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Rational Design of Metal Organic Framework Nanocarrier-Based Codelivery System of Doxorubicin Hydrochloride/Verapamil Hydrochloride for Overcoming Multidrug Resistance with Efficient Targeted Cancer Therapy.基于金属有机骨架纳米载体的盐酸多柔比星/盐酸维拉帕米共递送系统的合理设计，用于克服多药耐药性并实现高效靶向癌症治疗。
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The role of a novel copper complex in overcoming doxorubicin resistance in Ehrlich ascites carcinoma cells in vivo.一种新型铜络合物在体内克服艾氏腹水癌细胞多柔比星耐药性中的作用。
Chem Biol Interact. 2006 Feb 1;159(2):90-103. doi: 10.1016/j.cbi.2005.10.044. Epub 2005 Nov 10.
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Reversing Multidrug Resistance in Chemo-resistant Human Lung Adenocarcinoma (A549/DOX) Cells by Algerian Propolis Through Direct Inhibiting the P-gp Efflux-pump, G0/G1 Cell Cycle Arrest and Apoptosis Induction.阿尔及利亚蜂胶通过直接抑制P-糖蛋白外排泵、诱导G0/G1期细胞周期阻滞和凋亡来逆转人肺腺癌化疗耐药细胞（A549/DOX）的多药耐药性
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Doxorubicin-NO Releaser Molecular Hybrid Activatable by Green Light to Overcome Resistance in Breast Cancer Cells.可被绿光激活以克服乳腺癌细胞耐药性的阿霉素-NO释放分子杂化物
ACS Omega. 2022 Feb 24;7(9):7452-7459. doi: 10.1021/acsomega.1c03988. eCollection 2022 Mar 8.
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Coencapsulated doxorubicin and bromotetrandrine lipid nanoemulsions in reversing multidrug resistance in breast cancer in vitro and in vivo.共包封阿霉素和白屈菜红碱的脂质纳米乳剂在体外和体内逆转乳腺癌多药耐药性的研究
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Overcoming multidrug resistance using folate receptor-targeted and pH-responsive polymeric nanogels containing covalently entrapped doxorubicin.使用叶酸受体靶向和 pH 响应性聚合物纳米凝胶，其中包含共价包封的阿霉素，克服多药耐药性。
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Reversal of doxorubicin resistance in multidrug resistant melanoma cells in vitro and in vivo by dipyridamole.双嘧达莫在体外和体内逆转多药耐药黑色素瘤细胞对阿霉素的耐药性
Methods Find Exp Clin Pharmacol. 1997 May;19(4):231-9.
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Sequential therapy with redox-responsive glucolipid nanocarrier separately delivering siRNA and doxorubicin to overcome multidrug resistance.采用氧化还原响应性糖脂纳米载体进行序贯治疗，分别递送 siRNA 和阿霉素以克服多药耐药性。
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Overcoming Drug Resistance by Targeting Cancer Bioenergetics with an Activatable Prodrug.通过用可激活前药靶向癌症生物能量学来克服耐药性。
Chem. 2018 Oct 11;4(10):2370-2383. doi: 10.1016/j.chempr.2018.08.002. Epub 2018 Aug 23.
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A Supramolecular Nanoassembly of Lenvatinib and a Green Light-Activatable NO Releaser for Combined Chemo-Phototherapy.一种用于联合化疗-光疗的乐伐替尼与绿光可激活一氧化氮释放剂的超分子纳米组装体。
Pharmaceutics. 2022 Dec 28;15(1):96. doi: 10.3390/pharmaceutics15010096.
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Overcoming drug resistance in glioblastoma: new options in sight?克服胶质母细胞瘤中的耐药性：新的选择在望？
Cancer Drug Resist. 2021 Jun 19;4(2):512-516. doi: 10.20517/cdr.2021.03. eCollection 2021.
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Enhancing the Anticancer Activity of Sorafenib through Its Combination with a Nitric Oxide Photodelivering β-Cyclodextrin Polymer.通过与一氧化氮光递 β-环糊精聚合物联合增强索拉非尼的抗癌活性。
Molecules. 2022 Mar 16;27(6):1918. doi: 10.3390/molecules27061918.
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Doxorubicin-NO Releaser Molecular Hybrid Activatable by Green Light to Overcome Resistance in Breast Cancer Cells.可被绿光激活以克服乳腺癌细胞耐药性的阿霉素-NO释放分子杂化物
ACS Omega. 2022 Feb 24;7(9):7452-7459. doi: 10.1021/acsomega.1c03988. eCollection 2022 Mar 8.
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Exploring new Horizons in overcoming P-glycoprotein-mediated multidrug-resistant breast cancer via nanoscale drug delivery platforms.通过纳米级药物递送平台探索克服P-糖蛋白介导的多药耐药性乳腺癌的新视野。
Curr Res Pharmacol Drug Discov. 2021 Sep 6;2:100054. doi: 10.1016/j.crphar.2021.100054. eCollection 2021.
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Stimuli Responsive Nitric Oxide-Based Nanomedicine for Synergistic Therapy.用于协同治疗的刺激响应型一氧化氮基纳米药物
Pharmaceutics. 2021 Nov 12;13(11):1917. doi: 10.3390/pharmaceutics13111917.
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Carbon Dots: An Innovative Tool for Drug Delivery in Brain Tumors.碳点：脑肿瘤药物递送的创新工具。
Int J Mol Sci. 2021 Oct 29;22(21):11783. doi: 10.3390/ijms222111783.
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Protein Phosphorylation in Cancer: Role of Nitric Oxide Signaling Pathway.蛋白质磷酸化在癌症中的作用：一氧化氮信号通路。
Biomolecules. 2021 Jul 10;11(7):1009. doi: 10.3390/biom11071009.
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A generator of peroxynitrite activatable with red light.一种可被红光激活的过氧亚硝酸盐生成器。
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本文引用的文献
1
Overcoming multidrug resistance by targeting mitochondria with NO-donating doxorubicins.通过使用可释放一氧化氮的阿霉素靶向线粒体来克服多药耐药性。
Bioorg Med Chem. 2016 Mar 1;24(5):967-75. doi: 10.1016/j.bmc.2016.01.021. Epub 2016 Jan 14.
2
Carbonic anhydrase XII is a new therapeutic target to overcome chemoresistance in cancer cells.碳酸酐酶XII是克服癌细胞化疗耐药性的一个新的治疗靶点。
Oncotarget. 2015 Mar 30;6(9):6776-93. doi: 10.18632/oncotarget.2882.
3
Cancer cell metabolism and the modulating effects of nitric oxide.癌细胞代谢与一氧化氮的调节作用。
Free Radic Biol Med. 2015 Feb;79:324-36. doi: 10.1016/j.freeradbiomed.2014.11.012. Epub 2014 Nov 22.
4
Nano carriers that enable co-delivery of chemotherapy and RNAi agents for treatment of drug-resistant cancers.用于递送化疗药物和 RNAi 药物的纳米载体，用于治疗耐药性癌症。
Biotechnol Adv. 2014 Sep-Oct;32(5):1037-50. doi: 10.1016/j.biotechadv.2014.05.006. Epub 2014 Jun 9.
5
Nitric oxide donor doxorubicins accumulate into Doxorubicin-resistant human colon cancer cells inducing cytotoxicity.一氧化氮供体阿霉素可累积进入耐阿霉素的人结肠癌细胞，诱导细胞毒性。
ACS Med Chem Lett. 2011 Apr 4;2(7):494-7. doi: 10.1021/ml100302t. eCollection 2011 Jul 14.
6
Targeting the Achilles heel of multidrug-resistant cancer by exploiting the fitness cost of resistance.通过利用耐药性的适应性代价来靶向多药耐药癌症的致命弱点。
Chem Rev. 2014 Jun 11;114(11):5753-74. doi: 10.1021/cr4006236. Epub 2014 Apr 23.
7
Intercalation of antitumor drug doxorubicin and its analogue by DNA duplex: structural features and biological implications.抗肿瘤药物阿霉素及其类似物与DNA双链的嵌入作用：结构特征及生物学意义
Int J Biol Macromol. 2014 May;66:144-50. doi: 10.1016/j.ijbiomac.2014.02.028. Epub 2014 Feb 20.
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Small and Innovative Molecules as New Strategy to Revert MDR.作为逆转多药耐药的新策略的小分子创新药物
Front Oncol. 2014 Jan 21;4:2. doi: 10.3389/fonc.2014.00002. eCollection 2014.
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Photochemical delivery of nitric oxide.光化学递送一氧化氮。
Nitric Oxide. 2013 Nov 1;34:56-64. doi: 10.1016/j.niox.2013.02.001. Epub 2013 Feb 13.
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How does doxorubicin work?阿霉素是如何起作用的？
Elife. 2012 Dec 18;1:e00387. doi: 10.7554/eLife.00387.
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