Sharaf El Din Usama A, Salem Mona M, Abdulazim Dina O
Nephrology Unit, Internal Medicine Department, School of Medicine, Cairo University, Egypt.
Endocrinology Unit, Internal Medicine Department, School of Medicine, Cairo University, Egypt.
J Adv Res. 2017 May;8(3):271-278. doi: 10.1016/j.jare.2017.02.003. Epub 2017 Feb 27.
The death rate among chronic kidney disease patients is the highest compared to other chronic diseases. 60% of these fatalities are cardiovascular. Cardiovascular calcifications and chronic inflammation affect almost all chronic kidney disease patients and are associated with cardiovascular mortality. Fibroblast growth factor 23 is associated with vascular calcification. Systemic inflammation in chronic kidney disease patients is multifactorial. The role of systemic inflammation in the pathogenesis of vascular calcification was recently reappraised. Fibroblast growth factor 23 was accused as a direct stimulus of left ventricular hypertrophy, uremic inflammation, and impaired neutrophil function. This review will discuss the underlying mechanisms that underlie the link between Fibroblast growth factor 23 and increased mortality encountered among chronic kidney disease patients.
与其他慢性疾病相比，慢性肾病患者的死亡率最高。这些死亡案例中有60%是心血管疾病导致的。心血管钙化和慢性炎症几乎影响所有慢性肾病患者，并与心血管疾病死亡率相关。成纤维细胞生长因子23与血管钙化有关。慢性肾病患者的全身炎症是多因素导致的。全身炎症在血管钙化发病机制中的作用最近得到了重新评估。成纤维细胞生长因子23被认为是左心室肥厚、尿毒症炎症和中性粒细胞功能受损的直接刺激因素。本综述将讨论成纤维细胞生长因子23与慢性肾病患者死亡率增加之间联系的潜在机制。
