氟吡汀与阿片受体激动性镇痛药在大鼠中的比较性身体依赖性研究。
Comparative physical dependence studies in rats with flupirtine and opiate receptor stimulating analgesics.
作者信息
Nickel B, Aledter A
机构信息
Biological Research Pharmacology, Homburg Degussa Pharma Gruppe, Frankfurt, Federal Republic of Germany.
出版信息
Postgrad Med J. 1987;63 Suppl 3:41-3.
PMID:2833735
Abstract
In physical dependence studies in rats the principle criterion was loss of body weight after withdrawal of the dependence producing drug. Other typical signs of withdrawal were also observed. In contrast to buprenorphine, codeine and tramadol, flupirtine caused no decrease in body weight and no other withdrawal symptoms. Flupirtine does not produce opiate type physical dependence.
摘要
在对大鼠进行的身体依赖性研究中，主要标准是停用产生依赖性的药物后体重减轻。还观察到了其他典型的戒断症状。与丁丙诺啡、可待因和曲马多不同，氟吡汀不会导致体重下降，也不会出现其他戒断症状。氟吡汀不会产生阿片类身体依赖性。
Zotero 插件