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本文引用的文献

1
pGlyco: a pipeline for the identification of intact N-glycopeptides by using HCD- and CID-MS/MS and MS3.pGlyco：一种利用高能碰撞解离（HCD）和碰撞诱导解离（CID）串联质谱（MS/MS）以及三级质谱（MS3）鉴定完整N-糖肽的流程。
Sci Rep. 2016 May 3;6:25102. doi: 10.1038/srep25102.
2
Automated Glycan Sequencing from Tandem Mass Spectra of N-Linked Glycopeptides.糖肽的串联质谱自动化糖链测序。
Anal Chem. 2016 Jun 7;88(11):5725-32. doi: 10.1021/acs.analchem.5b04858. Epub 2016 May 23.
3
GPQuest: A Spectral Library Matching Algorithm for Site-Specific Assignment of Tandem Mass Spectra to Intact N-glycopeptides.GPQuest：一种用于串联质谱图到完整 N-糖肽的特定位点分配的光谱库匹配算法。
Anal Chem. 2015;87(10):5181-8. doi: 10.1021/acs.analchem.5b00024. Epub 2015 May 6.
4
MAGIC: an automated N-linked glycoprotein identification tool using a Y1-ion pattern matching algorithm and in silico MS² approach.MAGIC：一种使用Y1离子模式匹配算法和计算机模拟MS²方法的自动化N-连接糖蛋白识别工具。
Anal Chem. 2015 Feb 17;87(4):2466-73. doi: 10.1021/ac5044829. Epub 2015 Jan 28.
5
Automated annotation and quantitation of glycans by liquid chromatography/electrospray ionization mass spectrometric analysis using the MultiGlycan-ESI computational tool.使用MultiGlycan-ESI计算工具通过液相色谱/电喷雾电离质谱分析对聚糖进行自动注释和定量。
Rapid Commun Mass Spectrom. 2015 Jan 15;29(1):135-42. doi: 10.1002/rcm.7093.
6
GlycoMaster DB: software to assist the automated identification of N-linked glycopeptides by tandem mass spectrometry.糖基大师数据库：通过串联质谱法辅助自动识别N-连接糖肽的软件。
J Proteome Res. 2014 Sep 5;13(9):3881-95. doi: 10.1021/pr401115y. Epub 2014 Aug 25.
7
Automated annotation and quantification of glycans using liquid chromatography-mass spectrometry.利用液相色谱-质谱联用技术对聚糖进行自动化注释和定量。
Bioinformatics. 2013 Jul 1;29(13):1706-7. doi: 10.1093/bioinformatics/btt190. Epub 2013 Apr 22.
8
Software for automated interpretation of mass spectrometry data from glycans and glycopeptides.聚糖和糖肽的质谱数据自动解释软件。
Analyst. 2013 May 21;138(10):2793-803. doi: 10.1039/c2an36042j.
9
Byonic: advanced peptide and protein identification software.Byonic：先进的肽段和蛋白质鉴定软件。
Curr Protoc Bioinformatics. 2012 Dec;Chapter 13:13.20.1-13.20.14. doi: 10.1002/0471250953.bi1320s40.
10
The glycolyzer: automated glycan annotation software for high performance mass spectrometry and its application to ovarian cancer glycan biomarker discovery.糖基化分析软件：用于高性能质谱分析的自动化糖基化注释软件及其在卵巢癌糖基化生物标志物发现中的应用。
Proteomics. 2012 Aug;12(15-16):2523-38. doi: 10.1002/pmic.201100273.

基于质谱法的糖基化分析的生物信息学工具简要综述

A Brief Review of Bioinformatics Tools for Glycosylation Analysis by Mass Spectrometry.

作者信息

Tsai Pei-Lun, Chen Sung-Fang

机构信息

Department of Chemistry, National Taiwan Normal University; Mithra Biotechnology Inc.

Department of Chemistry, National Taiwan Normal University.

出版信息

Mass Spectrom (Tokyo). 2017;6(Spec Iss):S0064. doi: 10.5702/massspectrometry.S0064. Epub 2017 Feb 24.

DOI:10.5702/massspectrometry.S0064
PMID:28337402
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5358406/
Abstract

The purpose of this review is to provide updated information regarding bioinformatic software for the use in the characterization of glycosylated structures since 2013. A comprehensive review by Woodin 138: 2793-2803, 2013 (ref. 1) described two main approaches that are introduced for starting researchers in this area; analysis of released glycans and the identification of glycopeptide in enzymatic digests, respectively. Complementary to that report, this review focuses on mass spectrometry related bioinformatics tools for the characterization of N-linked and O-linked glycopeptides. Specifically, it also provides information regarding automated tools that can be used for glycan profiling using mass spectrometry.

摘要

本综述的目的是提供自2013年以来用于糖基化结构表征的生物信息学软件的最新信息。Woodin于2013年发表的一篇全面综述（参考文献1，138: 2793 - 2803）介绍了该领域新手入门的两种主要方法，分别是对释放的聚糖进行分析以及在酶解产物中鉴定糖肽。与该报告相辅相成的是，本综述重点关注用于N - 连接和O - 连接糖肽表征的与质谱相关的生物信息学工具。具体而言，它还提供了有关可用于通过质谱进行聚糖分析的自动化工具的信息。