基于质谱法的糖基化分析的生物信息学工具简要综述
A Brief Review of Bioinformatics Tools for Glycosylation Analysis by Mass Spectrometry.
作者信息
Tsai Pei-Lun, Chen Sung-Fang
机构信息
Department of Chemistry, National Taiwan Normal University; Mithra Biotechnology Inc.
Department of Chemistry, National Taiwan Normal University.
出版信息
Mass Spectrom (Tokyo). 2017;6(Spec Iss):S0064. doi: 10.5702/massspectrometry.S0064. Epub 2017 Feb 24.
Abstract
The purpose of this review is to provide updated information regarding bioinformatic software for the use in the characterization of glycosylated structures since 2013. A comprehensive review by Woodin 138: 2793-2803, 2013 (ref. 1) described two main approaches that are introduced for starting researchers in this area; analysis of released glycans and the identification of glycopeptide in enzymatic digests, respectively. Complementary to that report, this review focuses on mass spectrometry related bioinformatics tools for the characterization of N-linked and O-linked glycopeptides. Specifically, it also provides information regarding automated tools that can be used for glycan profiling using mass spectrometry.
摘要
本综述的目的是提供自2013年以来用于糖基化结构表征的生物信息学软件的最新信息。Woodin于2013年发表的一篇全面综述（参考文献1，138: 2793 - 2803）介绍了该领域新手入门的两种主要方法，分别是对释放的聚糖进行分析以及在酶解产物中鉴定糖肽。与该报告相辅相成的是，本综述重点关注用于N - 连接和O - 连接糖肽表征的与质谱相关的生物信息学工具。具体而言，它还提供了有关可用于通过质谱进行聚糖分析的自动化工具的信息。
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